C反应蛋白检测在COPD急性加重期的诊断价值

目的探讨C反应蛋白（CRP）在慢性阻塞性肺疾病（COPD）的急性加重期临床价值。方法检测慢性阻塞性肺疾病的急性加重期细菌感染的86名患者人院后第l、3d及出院前1dCRP,WBC,ESR,同时观察日体温和咳嗽频率、程度、痰颜色,同时给予抗生素治疗,并比较治疗前后这些指标的变化情况。结果 C反应蛋白在患者入院时的阳性率为100%,明显高于其他常规指标,在治疗后,CRP在常规检测指标还未有显著变化时已经明显下降,并与临床的症状相一致,其治疗前后的差异具有统计学意义（P〈0.01）。结论 CRP在COPD急性加重期是一个良好的观察指标,可反映抗生素的即时疗效,比WBC,ESR更快速且敏感。

Value of detection of C-reactive protein in diagnosis of acute exacerbation of chronic obstructive pulmonary disease

Aim To expore the significance of detection of C-reactive protein （CRP） in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods C-reactive protein,white blood cell and erythrocyte sedimentation rate （ESR） in 86 bacterial infected patients with acute exacerbation of chronic obstructive pulmonary disease were detected in the first and the third day of hospitalization and one day before being discharged from hospital,. The patients were treated with antibiotics . Results The positive rate of C-reactive protein in patients was 100% in the first day of hospitalization. Before and after treatment ,the conventional indicators were not changed significantly,but the level of C-reactive protein decreased significantly （P〈0.01）. Conclusions The level of C-reactive protein is a good indicators for diagnosis of acute exacerbation of chronic obstructive pulmonary disease ,which can reflect the immediate therapeutic effect rapidly that the inciators of white blood cell and erythrocyte sedimentation rate.