| 腺相关病毒载体在肺疾病基因治疗中的应用 |
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| 引用本文： | 吴剑卿,许伟,李燕.腺相关病毒载体在肺疾病基因治疗中的应用[J].国际呼吸杂志,2007,27(10):777-781. |
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| 作者姓名： | 吴剑卿 许伟 李燕 |
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| 作者单位： | 210029,南京医科大学第一附属医院老年医学科 |
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| 基金项目： | 江苏省自然科学基金项目（编号：BK2006244） |
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| 摘 要： | 腺相关病毒（adeno-associated virus,AAV）载体具有安全性好、免疫原性低、能感染分裂细胞和非分裂细胞、能介导基因的长期稳定表达等优点。因此,作为一种基因导入系统,重组AAV载体在基因治疗的研究和开发中受到越来越多的关注和重视。本文着重就重组AAV载体在肺部疾病基因治疗中的应用以及改进重组AAV载体的策略作简要综述。
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| 关 键 词： | 腺相关病毒 载体 肺疾病 基因治疗 |
| 修稿时间： | 2006-11-07 |
Adeno-associated virus vectors in gene therapy for lung diseases |
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| WU Jian-qing,XU Wei,LI Yan.Adeno-associated virus vectors in gene therapy for lung diseases[J].International Journal of Respiration,2007,27(10):777-781. |
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| Authors: | WU Jian-qing XU Wei LI Yan |
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| Institution: | Department of Geriatrics,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Adeno-associated virus(AAV) vectors are characterized as non-pathogenic,low immune responses,infectious of dividing and non-dividing cells and long-term expression of delivered gene.AAV has gained attention as a potentially safe vector for gene transfer and gene therapy.In this review,we will attempt to provide a brief introduction of the use of AAV vectors as a tool for therapeutic gene transfer in lung diseases,and strategies of enhancing the transduction efficiency of recombinant AAV vectors. |
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| Keywords: | Adeno-associated viru Vectors Lung disease Gene therapy |
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