细胞表面ATP合酶的研究进展

在细胞能量转变过程中，线粒体ATP合酶是一个关键酶。一般认为ATP合酶严格定位于线粒体膜上。但迄今已发现，该酶还在新生血管内皮细胞膜、某些类型的肿瘤细胞膜和脂肪细胞等细胞的膜上分布，而在正常细胞上却没有。利用细胞膜上存在ATP合酶的这个特性，已进行了许多血管形成、肿瘤抑制和脂类代谢等方面的功能研究，对该现象的机制也进行了初步地阐释。该文将对现有的研究结果作一综述。

Research advances in cell surface ATP synthase

Mitochondria ATP synthase is a key enzyme in cellular energy interconversion.It is generally believed that ATP synthase is strictly confined to mitochondria.However,it has been demonstrated that ATP synthase also occurs on the extracellular surface of vascular endothelial cells,tumor cells and adipocytes,instead of normal cells.Based on this characteristic,many functional researches have been conducted on the angiogenesis,tumor inhibition and lipid metabolism, and the mechanism on which this enzyme works ha...