Serum levels of inhibin B, unlike inhibin A and activin A, are not altered in women with preeclampsia |
| |
Authors: | Yair D Eshed-Englender T Kupferminc M J Geva E Frenkel J Sherman D |
| |
Institution: | Department of Obstetrics and Gynecology, Ma'ayani Hyeshua Hospital, Bnai Brak, Israel. danzv@green.co.il |
| |
Abstract: | PROBLEM: To investigate whether inhibin A, inhibin B, and activin A serum levels are altered in women with preeclampsia. METHOD OF STUDY: Serum samples of 20 women with preeclampsia (study group) and 20 normotensive pregnant women, matched for maternal and gestational age and parity, were assayed for inhibin A, inhibin B and activin A by specific enzyme-linked immunosorbent assay. RESULTS: Median serum concentrations of inhibin A and activin A were significantly higher among women with preeclampsia than in women with normotensive pregnancies, while inhibin B levels were comparable in both groups. Activin A levels were positively correlated with those of inhibins A and B, and inhibin A levels were positively correlated with diastolic blood pressure and inhibin B concentration in the study group. CONCLUSIONS: Inhibin A and activin A, but not inhibin B, serum levels are markedly increased in women with preeclampsia. These hormones might serve as an endocrine marker for preeclampsia. |
| |
Keywords: | Activin A inhibin A inhibin B preeclampsia serum markers |
本文献已被 PubMed 等数据库收录! |
|