黄芪发酵粉对环磷酰胺的增效和减毒作用研究

目的:研究黄芪发酵粉(FAP)对肿瘤化疗药物环磷酰胺(Cy)的增效和减毒作用,探索临床上更经济有效的抗癌化疗辅助用药。方法:增效实验采用小鼠移植性肿瘤模型(S180、H22实体瘤和H22腹水瘤),观察FAP与Cy合用对肿瘤抑制率和生命延长率的影响;减毒实验观察FAP对大剂量Cy所致小鼠骨髓抑制、免疫器官萎缩、肾功能损伤等毒性反应的对抗作用。结果:FAP可增强Cy对小鼠S180、H22实体瘤的抑瘤作用;对抗Cy所致小鼠外周血白细胞减少、骨髓有核细胞数减少和脾重减轻等毒性反应,保护肾功能,对肝功能无显著影响。结论:FAP对肿瘤化疗药物Cy有增效和减毒作用。

Synergism and Attenuation of Fermented Radix Astragali Powder on Cyclophosphamide

OBJECTIVE:To observe the synergism and attenuation of Fermented Radix Astragali Powder(FAP)on Cyc-lophosphamide(Cy),a tumor chemotherapeutics,and to explore more economical and effective assistant chemotherapeutics.METHODS:In synergism experiments,the mice tumor models(S180 and H22 solid tumor and H22 ascitic tumor)were used to observe the effects of FAP combined with Cy on tumor control rate and survival time of mice.In attenuation experiments,the effects of FAP against toxic reactions including myelosuppression,atrophy of immune organs,and lesions on renal function induced by high dose of Cy in mice were observed.RESULTS:FAP did enhanced the the antitumor effect of Cy on S180 and H22 solid tumor,lessened Cy-induced toxic reactions such as aleucocytosis,the reduction of the nucleated cells in bone marrow and the weight loss of spleen in mice,meanwhile,it showed protective effect on renal function yet without no significant influence on hepatic function.CONCLUSION:FAP has synergistic and attenuation effects on Cy.