| 胚胎干细胞在预测毒理学中的应用前景 |
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| 引用本文： | 吴萍,于爱莲. 胚胎干细胞在预测毒理学中的应用前景[J]. 中国病原生物学杂志, 2011, 0(1) |
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| 作者姓名： | 吴萍 于爱莲 |
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| 作者单位： | 泰山医学院病原学教研室; |
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| 基金项目： | 山东省科技攻关项目(No.2007GG30002016) |
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| 摘 要： | 建立和完善既短期、经济,又能大通量筛检环境污染物对人类的毒性一直是预测毒理学中主要研究热点。胚胎干细胞具有自我更新和多向分化的特性,有望成为毒性安全性评价的体外替代实验模型。本文主要对预测毒理学现有方法的缺陷、胚胎干细胞的生物学特性和在预测毒理学中的应用研究进展进行综述。
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| 关 键 词： | 胚胎干细胞 胚胎毒性 预测毒理学 综述 |
Prospects for use of embryonic stem cells in predictive toxicology |
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| WU Ping,YU Ai-lian. Prospects for use of embryonic stem cells in predictive toxicology[J]. Journal of Pathogen Biology, 2011, 0(1) |
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| Authors: | WU Ping YU Ai-lian |
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| Affiliation: | WU Ping,YU Ai-lian(Department of Etiology,Taishan Medical College,Taian 271000,Shandong,China) |
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| Abstract: | Determining and improving the time taken,cost,and also high-throughput screening of the toxicity of environmental pollutants in humans have been the key objectives of predictive toxicology.Embryonic stem(ES) cells have characteristics of self-renewal and differentiation and are expected to serve as an alternative experimental model for the evaluation of toxicity and safety.This article provides an overview of the shortcomings of existing methods of predictive toxicology,biological characteristics of ES cell... |
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| Keywords: | Embryonic stem cells embryotoxicity predictive toxicology review |
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