| 中药加味四逆散对血吸虫病小鼠肝功能的影响 |
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| 引用本文： | 李珊,蔡锐,伍参荣,申可佳,左胜男.中药加味四逆散对血吸虫病小鼠肝功能的影响[J].中国病原生物学杂志,2011(1). |
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| 作者姓名： | 李珊 蔡锐 伍参荣 申可佳 左胜男 |
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| 作者单位： | 湖南中医药大学基础医学院病原免疫学教研室; |
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| 基金项目： | 湖南省科技厅资助项目(No.04sk1007-26) |
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| 摘 要： | 目的观察加味四逆散对血吸虫病肝纤维化小鼠肝功能的影响。方法NI H小鼠经皮肤人工感染血吸虫尾蚴后随机分为4组:B组(模型组)、C组(吡喹酮组)、D组(吡喹酮+加味四逆散组)和E组(吡喹酮+秋水仙碱组),同时设A组(正常对照组)。病理观察小鼠肝组织肝纤维化形成后第21 d开始给药治疗,C组、D组、E组在第45 d时予以吡喹酮一次性灌胃杀虫,第78 d心脏采血,生物化学法测血清ALT、TBiL及血浆ALB含量,取肝、脾组织称重,计算脏器系数。结果吡喹酮+加味四逆散组小鼠治疗后肝脏系数低于模型组、吡喹酮组、吡喹酮+秋水仙碱组(P<0.05),高于正常对照组(P<0.05);脾脏系数低于模型治疗组和吡喹酮组(P<0.05),与吡喹酮+秋水仙碱组比较差异无统计学意义(P>0.05);血清ALT、AST水平与模型组、吡喹酮组、吡喹酮+秋水仙碱组比较差异有统计学意义(P<0.05),TBiL水平与模型组、吡喹酮组比较差异有统计学意义(P<0.05),与吡喹酮+秋水仙碱组比较差异无统计学意义(P>0.05);ALB水平高于模型组(P<0.05),低于正常对照组(P<0.05)。结论中药加味四逆散联合吡喹酮治疗能有效改善血吸虫...
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| 关 键 词： | 血吸虫病 肝功能 加味四逆散 吡喹酮 秋水仙碱 |
Effect of modified SiNi powder(Jiawei Sinisan) on liver function in mice infected with Schistosoma japonicum |
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| LI Shan,CAI Rui,WU Can-rong,SHEN Ke-jia,ZUO Sheng-nan.Effect of modified SiNi powder(Jiawei Sinisan) on liver function in mice infected with Schistosoma japonicum[J].Journal of Pathogen Biology,2011(1). |
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| Authors: | LI Shan CAI Rui WU Can-rong SHEN Ke-jia ZUO Sheng-nan |
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| Institution: | LI Shan,CAI Rui,WU Can-rong,SHEN Ke-jia,ZUO Sheng-nan(Departmeng of Pathogenic Biology and Immunology,Preclinical Medicine College,Hunan Chinese Medical University,Changsha 410208,China) |
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| Abstract: | Objective To evaluate the effect of modified SiNi powder,known as Jiawei Sinisan(JWSNS),on liver function in a murine model of liver fibrosis induced by Schistosoma japonicum infection.Methods Liver fibrosis was successfully induced in NIH mice by infection with cercaria of S.japonicum and then mice were randomly divided into groups B,C,D and E.The mice in groups C,D,and E were treated with praziquantel,praziquantel plus JWSNS,and praziquantel plus colchicine,respectively.In addition,a group of uninfected N... |
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| Keywords: | Schistosomiasis liver function JWSNS praziquantel colchicine |
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