吉西他滨治疗14例晚期胰腺癌

目的：研究吉西他滨（gemcitabine)治疗晚期胰腺癌的疗效。方法：14例进行展期胰腺癌患者，用吉西他滨第1周800mg/m^2，第2周1000mg/m^2，第3周1200mg/m^2，每周1次，每次以0．9％生理盐水100ml溶解后静脉滴注，30分钟滴完，连续3周，随后休息1周为一疗程。以后每4周重复一次，共6个疗程。结果：疼痛缓解有效率为64％（9／14），处长了中位生存期，平均为8．7个月。临床受益反应为43％。吉西他滨治疗晚期胰腺癌能显著改善晚期胰腺癌患者的临床症状，减轻疼痛。生活质量有明显提高。结论：吉西他滨可作为晚期胰腺癌综合治疗时首选的化疗药物。

Treatment with gemcitabine in 14 cases with advanced pancreatic cancer

Purpose:To observe the effects of chemotherapy with gemcitabine in advanced pancreatic cancer.Methods:Fourteen patients with advanced pancreatic cancer were treated with gemcitabine in doses of 800 mg/m2 first week, 1 000 mg/m2on second week and 1 200 mg/m2 on third week.The drug was diluted in 100ml of normal saline and administered intravenously over 30 minutes.Gemcitabine was administered once a week for 3 consecutive weeks out of every 4 weeks, a cycle defined as one 4-week period, total 6 cycles.Results:Nine patients of 14 had an improvement in pain. Median survival duration was 8.7 months and clinical beneficial response was 43%. Clinical symptoms were markedly improved in patients with advanced-stage pancreatic cancer. Severity of pain, analgesic consumption, patients' QOL and survival period were greatly improved. Conclusions:It is suggested that gemcitabine be a favorable, helpful chemotherapy in advanced pancreatic cancer.