Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems |
| |
| Authors: | T W Schultz G W Holcombe G L Phipps |
| |
| Affiliation: | 1. College of Veterinary Medicine, University of Tennessee, P.O. Box 1071, Knoxville, Tennessee 37901, USA;2. U.S. Environmental Protection Agency, Environmental Research Laboratory-Duluth, 6201 Congdon Boulevard, Duluth, Minnesota 55804 USA;1. Physic Laboratory of Thin Films and Applications LPCMA, University of Biskra, Algeria;2. Laboratoire de Couches Minces et Interfaces Faculté des Sciences Université de Constantine, Algeria;3. Laboratoire de Photovoltaïque, Centre de Recherche et des Technologies de l’Energie, Technopole de Borj-Cédria, BP 95, 2050 Hammam-Lif, Tunisia;1. Department of Mechanical and Electronic Engineering, Jiangsu Polytechnic of Finance & Economics, Huai''an, Jiangsu 223003, PR China;2. Faculty of Mathematics and Physics, Huaiyin Institute of Technology, Huai''an, Jiangsu 223003, PR China;1. School of Electronic Science & Engineering, Southeast University, Nanjing 210096, Jiangsu Province, People''s Republic of China;2. School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, Jiangsu Province, People''s Republic of China;3. School of Physics, Alagappa University, Karaikudi 630004, India;4. Department of Physics, Annamalai University, Annamalainagar 608002, India;1. Commissariat à l׳énergie atomique et aux énergies alternatives (CEA, LITEN-DTNM –SEN-LSIN), 17 rue des martyrs, 38054 Grenoble Cedex 9, France;2. Screen-Solar, La Petite Maison ZEN, 390 Route de la Traverse, 73 000 Montagnole, France;3. Laboratoire de Génie des Procédés Papetiers, UMR CNRS 5518, 461 rue de la Papeterie, CS 10065, 38402 Saint-Martin d’Hères Cedex, France;1. Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349 Oslo, Norway;2. Norwegian University of Life Sciences (NMBU), Faculty of Environmental Sciences and Natural Resource Management (MINA), P.O. Box 5003, N-1432 Ås, Norway;3. Centre for Environmental Radioactivity (CERAD), Norwegian University of Life Sciences (NMBU), Post Box 5003, N-1432 Ås, Norway |
| |
| Abstract: | The relative toxic response of 27 selected phenols in the 96-hr acute flowthrough Pimephales promelas (fathead minnow) and the 48- to 60-hr chronic static Tetrahymena pyriformis (ciliate protozoan) test systems was evaluated. Log Kow-dependent linear regression analyses revealed that the data from each test system consisted of two linear equations. The less toxic chemicals form a relationship which models polar narcosis; these chemicals are slightly more active than the baseline toxicity of nonionic narcotic chemicals. The more toxic chemicals form a relationship which models uncoupling of oxidative phosphorylation. Regression analysis of fathead minnow toxicity (log LC50 (mol/liter] vs Tetrahymena toxicity (log BR (mmol/liter] showed good correlation between the two systems. An exception appears to be 4-nitrophenol, which is more active in the Tetrahymena system than in the fathead minnow and lies outside the 95% confidence interval. Reanalysis following deletion of 4-nitrophenol results in the equation log LC50 = -0.9192 (log BR) -3.5035; n = 26, r2 = 0.887. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
