| 雌激素对去卵巢大鼠动脉中雌激素受体表达及血中一氧化氮含量的影响 |
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| 引用本文： | 刘国艺,姚兰春,程春红,傅羽,边淑玲,倪江. 雌激素对去卵巢大鼠动脉中雌激素受体表达及血中一氧化氮含量的影响[J]. 哈尔滨医科大学学报, 2003, 37(3): 196-197 |
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| 作者姓名： | 刘国艺 姚兰春 程春红 傅羽 边淑玲 倪江 |
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| 作者单位： | 1. 哈尔滨医科大学,生理学教研室,黑龙江,哈尔滨,150086
2. 哈尔滨医科大学,第二临床医学院,妇产科,黑龙江,哈尔滨,150086 |
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| 基金项目： | 黑龙江省自然科学基金资助项目(9933) |
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| 摘 要： | 目的探讨雌激素对去卵巢大鼠动脉中ER的表达及血清中NO含量的影响. 方法成年雌性大鼠切除卵巢后,随机分为两组①去卵巢+E2组,给予E2;②单纯去卵巢组,为对照.2个月后处死大鼠取材,用免疫组化法检测动脉中的ER表达,并分别用放免法和重氮法检测血清中的E2和NO.结果去卵巢+E2组大鼠动脉中ER的表达显著高于对照组,血清中NO含量也显著升高(P<0.001).结论雌激素能使去卵巢大鼠动脉中ER的表达增加,血清中NO的含量显著增加.这可能是雌激素对绝经后妇女心血管保护作用的机制之一.
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| 关 键 词： | 雌激素 去卵巢大鼠 动脉 雌激素受体 表达 血 一氧化氮 含量 影响 |
| 文章编号： | 1000-1905(2003)03-0196-02 |
| 修稿时间： | 2003-01-14 |
Effects of estrogen on the expression of estrogen receptors in arteries and serum nitric oxide in ovariectomized rats |
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| LIU Guo yi,YAO Lan chun,CHENG Chun hong,et al. Effects of estrogen on the expression of estrogen receptors in arteries and serum nitric oxide in ovariectomized rats[J]. Journal of Harbin Medical University, 2003, 37(3): 196-197 |
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| Authors: | LIU Guo yi YAO Lan chun CHENG Chun hong et al |
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| Abstract: | Objective To investigate the effects of estrogen on the expression of estrogen receptor(ER) in arteries and the serum NO in ovariectomized rats. Methods Adult female rats were randomly divided into two guoups: ovariectomy+E 2 group, injected with E 2; and ovariectomy group as control. Arteries and serum were collected 2 months after ovariectomy.ERs in arteries were detected by immunohistochemistry,and the concentrations of serum E 2 and NO were assayed by RIA and Griess reaction, respectively. Results The expression of ER in arteries of ovariectomy+E 2 group was increased significantly,and the concentration of serum NO was also increased significantly( P <0.001).Conclusion Estrogen could increase both the expression of ER in arteries and the concentration of serum NO in ovariectomized rats, which might suggest one of the mechanisms of estrogen on cardiovascular system in postmenopausal women. |
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| Keywords: | estrogen estrogen receptors nitric oxide rat |
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