| 腺苷预处理对体外循环术后心肌肌钙蛋白变化的影响 |
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| 引用本文： | 尹晓清,伍硕允,吴炎豪,张红环,刘宗贵,陈志锦. 腺苷预处理对体外循环术后心肌肌钙蛋白变化的影响[J]. 中国胸心血管外科临床杂志, 2000, 7(2): 86-88 |
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| 作者姓名： | 尹晓清 伍硕允 吴炎豪 张红环 刘宗贵 陈志锦 |
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| 作者单位： | 江门市中心医院,心胸外科,广东江门,529070 |
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| 基金项目： | 广东省医药卫生青年科研项目 |
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| 摘 要： | 目的 探讨腺苷预处理对心脏直视手术的心肌保护效果。方法 ３０例择期心瓣膜置换术患者随机分成实验组和对照组，每组１５例。实验组在术前行腺苷预处理。分别于转流前、主动脉阻断３０分钟和６０分钟、主动脉开放后３０分钟及术后２４小时采血测定心肌肌钙蛋白Ｔ（ｃＴｎＴ）、心肌酶谱和丙二醛。结果 腺苷预处理ｃＴｎＴ和心肌酶外漏明显减少，丙二醛生成减少。结论 腺苷预处理能减轻心肌肌缺血再灌注损伤。
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| 关 键 词： | 腺苷 缺血预处理 心肌肌钙蛋白 体外循环 |
The Effect of Adenosine Preconditioning on cTroponin after Extracorporeal Circulation |
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| YIN Xiao qing,WU Shuo yun,WU Yan hao,et al.. The Effect of Adenosine Preconditioning on cTroponin after Extracorporeal Circulation[J]. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2000, 7(2): 86-88 |
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| Authors: | YIN Xiao qing WU Shuo yun WU Yan hao et al. |
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| Affiliation: | YIN Xiao qing,WU Shuo yun,WU Yan hao,et al. Department of Cardiac and Thoracic Surgery,Jiangmen Central Hospital,Jiangmen 529070,Guangdong,P.R.China |
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| Abstract: | Objective To investigate the myocardial protective effects of adenosine preconditioning in patients undergoing open heart operation. Methods Tirty patients with cardiac valve replacement were randomly divided into experimental group and control group with 15 cases in each group. Adenosine preconditioning was elicited in experimental group before the extracorporeal circulation. cTroponin T(cTnT), myocardium enzymes and malondialdehyde were measured in each group respectively before bypass, 30 and 60 minutes after the aorta clamping, 30 minutes after the aorta off clamping, 24 hours after the operation. Results Adenosine preconditioning alleviated significantly the exudation of cTnT and myocardium enzymes, reduced the malondialdehyde content. Conclusion Adenosine preconditioning can reduce myocardium ischemic reperfusion injury. |
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| Keywords: | Adenosine Ischemic preconditioning cTroponin Extracorporeal circulation |
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