Proton magnetic resonance spectroscopy detects a relative decrease of N-acetylaspartate in the hippocampus of patients with dementia with Lewy bodies. |
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Authors: | Xiaqing Xuan Meiping Ding Xiangyang Gong |
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Affiliation: | Department of Neurology, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China. |
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Abstract: | BACKGROUND AND PURPOSE: To characterize the cerebral metabolic changes in dementia with Lewy bodies patients. METHODS: The metabolic ratios of NAA/Cr and Cho/Cr in bilateral hippocampus were determined by proton magnetic resonance spectroscopy in 8 patients and 8 age-matched healthy controls. RESULTS: Dementia with Lewy bodies patients showed significantly lower NAA/Cr ratios in bilateral hippocampus, while the Cho/Cr ratio did not differ from the control group. CONCLUSIONS: Our data show relatively decrease of N-acetylaspartate in the hippocampus of patients with early or intermediate stage DLB. Hence, damage of neurons seems to be an early alteration in DLB. |
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Keywords: | Diffuse Lewy body disease proton magnetic resonance spectroscopy N-acetylaspartate |
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