| 三江地区部分肝病患者血清中乙肝病毒基因型的检测 |
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| 引用本文： | 王春敏,马淑霞,李丽秋,佟丽波,韩桂华,张昆,宋淑贤,施中凯,杨春佳. 三江地区部分肝病患者血清中乙肝病毒基因型的检测[J]. 中国现代医学杂志, 2006, 16(4): 575-577 |
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| 作者姓名： | 王春敏 马淑霞 李丽秋 佟丽波 韩桂华 张昆 宋淑贤 施中凯 杨春佳 |
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| 作者单位： | 1. 佳木斯大学基础医学院,黑龙江,佳木斯,154007
2. 佳木斯大学临床医学院第一附属医院,黑龙江,佳木斯,154002 |
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| 摘 要： | 目的探究黑龙江省三江地区部分肝病患者血清中的乙肝病毒基因型。方法采用基因型特异引物的巢式聚合酶链式反应方法对29例乙肝携带者、9例急性肝炎、36例慢性肝炎、19例肝硬化和3例肝癌患者血清中HBV基因型进行分析。结果HBVB型31例（32．3％）、C型62例（64．6％）、有3例患者同时检出基因型B和C。结论三江地区存在HBVB和C型，而且C型为主要基因型，另外还有少数B、C型混合感染。
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| 关 键 词： | 乙型肝炎病毒 血清 基因型 巢式聚合酶链式反应 |
| 文章编号： | 1005-8982（2006）04-0575-03 |
| 收稿时间： | 2005-04-17 |
| 修稿时间： | 2005-04-17 |
HBV genotype in Sanjiang Region |
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| WANG Chun-min,MA Shu-xia,LI Li-qiu,TONG Li-bo,HAN Gui-hua,ZHANG Kun,SONG Shu-xian,SHI Zhong-kai,YANG Chun-jia. HBV genotype in Sanjiang Region[J]. China Journal of Modern Medicine, 2006, 16(4): 575-577 |
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| Authors: | WANG Chun-min MA Shu-xia LI Li-qiu TONG Li-bo HAN Gui-hua ZHANG Kun SONG Shu-xian SHI Zhong-kai YANG Chun-jia |
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| Affiliation: | 1.Basic Medical College of Jiamusi University, Jiamusi 154007, P.R.China;2. The First Affiliated Hospital of Jiamusi University, Jiamusi 154002, P.R.China |
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| Abstract: | [Objective] To determine the genotype of the hepatitis B virus ( HBV) of the Sanjiang Region, Heilongjiang province. [Methods] 29 HBV carriers, 9 patients with acute hepatitis, 36 patients with chronic hepatitis, 19 patients with hepatic cirrhosis and 3 patients with liver cancer had their serum HBV genotypes differentiated by the method of nested -polymerase chain reaction (NT-PCR) of genotype-specific sequences. [Results] HBV genotype B was found in 31 cases (32.2%) and genotype C in 62 cases (64.6%), and both genotype B and C coexisted in 3 cases (3.1%). [Conclusion] The results suggested that there were two genotypes: B and C HBV, the genotype C was the major genotype, and there were few cases who were coinfected by both genotype B and C HBV. |
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| Keywords: | hepatitis B virus serum genotype nested-polymerase chain reaction |
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