| LAK细胞可溶性因子介导K_(562)细胞的损伤 |
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| 引用本文： | 赵铁华,邓淑华,谢长顺,辛士芹,那金芝,钱巍.LAK细胞可溶性因子介导K_(562)细胞的损伤[J].承德医学院学报,1993(2). |
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| 作者姓名： | 赵铁华 邓淑华 谢长顺 辛士芹 那金芝 钱巍 |
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| 作者单位： | 承德医学院微生物学教研室，承德医学院微生物学教研室，承德医学院微生物学教研室，承德医学院附属医院，承德医学院附属医院，承德医学院附属医院 |
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| 摘 要： | 采用~(51)Cr释放方法探讨LAK细胞可溶性因子介导的K_(562)细胞的损伤。15例中有12例LAK细胞培养上清介导的K_(562)细胞的损伤为10.96±5.15％。将LAK细胞洗去培养上清后与K_(562)细胞共育6小时,5例此种效靶细胞共育后的上清介导的Ks6z细胞的损伤为12.41±6.54％。结果表明,LAK细胞杀伤K_(562)细胞的作用至少一部分是由LAK细胞分泌的可溶性因子完成的。
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| 关 键 词： | LAK细胞 可溶性因子 细胞毒 K_(562)细胞 |
LAK CELL KILLING ACTIVTTY MEDIATED BY RESOLVABLE FACTOR |
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| Zhao Tiehua,et al.LAK CELL KILLING ACTIVTTY MEDIATED BY RESOLVABLE FACTOR[J].Journal of Chengde Medical College,1993(2). |
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| Authors: | Zhao Tiehua |
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| Institution: | Zhao Tiehua,et al Department of Microbiology |
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| Abstract: | The damage effect of resolvabie factors released by LAK cells on K_(562) cells was observed with ~(51)Cr release assay. The mean killing activity of supernatant from culture fluid which was used for preparing LAK cells was 10.96 + 5.15% in 12 out of the tatol 15 cases,while that of the supernatant from coculture of the effector and target cells for 6 hours was 12.41+6.54%(n=5). These results indicate that the killing activity of LAK cells at least is partly due to the effect of resolvable factors released by LAK cells. |
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| Keywords: | LAK cells cytotoxic K_(562) cells resolvable factor |
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