| 正骨制剂对大鼠骨痂生长指数及耳廓微循环影响的实验研究 |
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| 引用本文： | 熊学华,张玉亮,王克刚,郭新辉,周玖瑶,王霞,陈丽敏.正骨制剂对大鼠骨痂生长指数及耳廓微循环影响的实验研究[J].海南医学,2009,20(10):4-5,3. |
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| 作者姓名： | 熊学华 张玉亮 王克刚 郭新辉 周玖瑶 王霞 陈丽敏 |
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| 作者单位： | 1. 中国人民解放军第421医院外二科,广东,广州,510318
2. 广州中医药大学中药学院药理教研室,广东,广州,510407 |
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| 基金项目： | 全军"十一五"中医药专项课题 |
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| 摘 要： | 目的观察正骨1号水剂、正骨2号散剂及正骨3号胶囊制剂治疗骨折的药效作用。方法采用SD大鼠,分别折断其右后胫骨造成闭合性骨折模型。取造模成功的骨折大鼠40只,随机分为模型组,正骨制剂高、低剂量组和阳性对照组,每组10只。在手术次日开始给药,连续30 d。正骨制剂高、低剂量组分别灌胃给予3.45 g/kg正骨3号胶囊水溶液、0.86 g/kg正骨3号胶囊水溶液,剂量0.1 ml/100 g,在大鼠右后肢骨折处涂抹正骨1号水剂和正骨2号散剂;阳性组灌胃给予0.37 g/kg云南白药水溶液,剂量0.1 ml/100 g,在大鼠右后肢骨折处涂抹伤科灵喷雾剂和云南白药;模型组灌胃给予蒸馏水,剂量0.1 ml/100 g。用骨折模型大鼠耳廓微循环检测评价药物的活血作用,用X线评价骨痂生长指数。结果正骨制剂系列药品能明显提高大鼠骨折动物模型的骨痂生长指数,促进骨折愈合;有增强骨折模型大鼠耳廓微动脉血流速度的趋势,可促进小鼠耳廓微循环。结论正骨系列制剂药品具有良好的治疗骨折的作用。
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| 关 键 词： | 正骨制剂 骨折大鼠 骨痂生长指数 耳廓微循环 |
Effect of Zhenggu preparation on index of the osteotylus formation and the microcirculation of auricle in the rats |
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| XIONG Xue-hua,ZHANG Yu-liang,WANG Ke-gang,et al..Effect of Zhenggu preparation on index of the osteotylus formation and the microcirculation of auricle in the rats[J].Hainan Medical Journal,2009,20(10):4-5,3. |
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| Authors: | XIONG Xue-hua ZHANG Yu-liang WANG Ke-gang |
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| Institution: | XIONG Xue-hua,ZHANG Yu-liang,WANG Ke-gang,et al.Department of the Second Surgery,the 421st Hospital of PLA,Guangzhou 510318,P.R.CHINA |
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| Abstract: | Objective To observe the effect of three kinds of Zhenggu preparation(liquor,powder and capsule)in the treatment of rats with the fracture.Methods Using SD rats,rat models with fracture were established,and then were randomly divided into model group,Zhenggu preparation high dose group,Zhenggu preparation low dose group and Yun-nan-bai-yao group.After the second day of operation,the rats were fed with saline,Zhenggu capsule and Yun-nan-bai-yao capsule respectively,and in the same time,the rats were applied ... |
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| Keywords: | Zhenggu preparation Fracture Index of osteotylus formation Microcirculation of auricle |
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