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Anti-NMDA receptor encephalitis with associated catatonia during pregnancy |
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| Authors: | A McCarthy J Dineen P McKenna M Keogan J Sheehan T Lynch K O’Rourke |
| Institution: | 1. Dublin Neurological Institute at the Mater Misericordiae University Hospital, 57 Eccles Street, Dublin 7, Ireland 2. Department of Obstetrics, Rotunda Hospital, Parnell Street, Dublin 1, Ireland 3. Department of Immunology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland 4. Department of Psychiatry, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland |
| Abstract: | Anti-NMDA-R encephalitis has been described as a cause of acute psychosis in young females. It is rare during pregnancy. We describe a primigravida 32-year-old woman with acute onset psychosis during the first trimester. Eight weeks after becoming pregnant, the patient became psychotic with associated catatonia and autonomic disturbance. Serum anti-NMDA-R antibodies were found. She responded to plasma exchange. At caesarean section, a healthy baby boy was born and a benign mature cystic teratoma was removed from the left ovary. Catatonia associated with psychosis may occur in pregnancy secondary to anti-NMDA-R encephalitis. Prompt and aggressive treatment can lead to a good outcome for both baby and mother. |
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