首页 | 本学科首页   官方微博 | 高级检索  
     

代谢重编程介导肿瘤免疫微环境重塑的现状和展望
引用本文:李星晨,邓红,于津浦. 代谢重编程介导肿瘤免疫微环境重塑的现状和展望[J]. 中国肿瘤生物治疗杂志, 2022, 29(2): 87-92
作者姓名:李星晨  邓红  于津浦
作者单位:天津医科大学肿瘤医院肿瘤分子诊断中心,国家肿瘤临床医学研究中心,天津市“肿瘤防治”重点实验室,天津恶性肿瘤临床医学研究中心,天津市肿瘤免疫与生物治疗重点实验室;天津医科大学总医院,天津市肺癌研究所
基金项目:国家自然科学基金面上项目(No. 82173198;No. 81872143)
摘    要:代谢重编程是肿瘤的特征之一,也是肿瘤治疗的重要潜在靶点。肿瘤和免疫细胞之间的相互作用对代谢重编程的影响是决定抗肿瘤免疫应答的关键因素之一。肿瘤代谢不仅在肿瘤发生和维持肿瘤细胞生存中发挥了关键作用,并且可以通过释放代谢产物,如乳酸、PGE2等来影响免疫细胞进而影响肿瘤免疫微环境。这种肿瘤细胞与免疫细胞之间的相互作用导致了肿瘤免疫微环境中的代谢竞争,限制了营养物质的正常代谢,形成酸性环境,最终导致抗肿瘤免疫反应减弱和免疫抑制性微环境的形成。此外,免疫细胞发生免疫应答的过程中存在代谢方式的改变,即在增殖、分化和执行细胞功能的过程中会发生代谢重编程。因此,了解肿瘤免疫微环境中肿瘤细胞和免疫细胞的代谢重编程的调节机制,可以使研究人员在抗肿瘤免疫治疗中获得靶向代谢途径的治疗思路。

关 键 词:代谢重编程;代谢产物;免疫治疗;肿瘤免疫微环境

Metabolic reprogramming mediates tumor immune microenvironment remodeling:current achievements and prospects
LI Xingchen,DENG Hong,YU Jinpu. Metabolic reprogramming mediates tumor immune microenvironment remodeling:current achievements and prospects[J]. Chinses Journal of Cancer Biotherapy, 2022, 29(2): 87-92
Authors:LI Xingchen  DENG Hong  YU Jinpu
Affiliation:Cancer Molecular Diagnostics Centre, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Malignant Cancer, Tianjin Key Laboratory of Cancer Immunology and Biotherapy;Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital
Abstract:Metabolic reprogramming is one of the characteristics of tumors and an important potential target for tumor therapy. The effect of the interaction between tumor and immune cells on metabolic reprogramming is one of the key factors determining the anti-tumor immune response. Tumor metabolism not only plays a key role in maintaining tumor genesis and survival, but also affects immune cells by releasing metabolites such as arginine and PGE2, thereby affecting the tumor immune microenvironment. The interaction between tumor cells and immune cells leads to metabolic competition in the tumor immune microenvironment, which limits the normal metabolism of nutrients and forms an acidic environment, and ultimately leads to a weakened anti-tumor immune response and the formation of an immunosuppressive microenvironment Moreover, there are alterations in metabolism of immune cells during the process of immune responses, that is metabolic reprogramming occurs in immune cells during their proliferation, differentiation and performance of cellular functions. Therefore, understanding the regulatory mechanism of metabolic reprogramming of tumor cells and immune cells in tumor immune microenvironment will enable researchers to find therapeutic means of targeting metabolic pathways in anti-tumor immunotherapy.
Keywords:metabolic reprogramming   metabolite   immunotherapy   tumor immune microenvironment
点击此处可从《中国肿瘤生物治疗杂志》浏览原始摘要信息
点击此处可从《中国肿瘤生物治疗杂志》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号