| VEGF和色素上皮衍生因子的表达失衡对糖尿病肾病的影响 |
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| 引用本文： | 李竞,李珍瑾,崔静,王蜀鄂,包艳,叶迎春.VEGF和色素上皮衍生因子的表达失衡对糖尿病肾病的影响[J].中华内分泌代谢杂志,2009,25(2). |
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| 作者姓名： | 李竞 李珍瑾 崔静 王蜀鄂 包艳 叶迎春 |
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| 作者单位： | 武汉大学人民医院内分泌科,430060 |
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| 摘 要： | 建立链脲佐菌素诱导的糖尿病大鼠模型,用免疫组化法观察肾小管间质血管内皮生长因子(VEGF)和色素上皮衍生因子(PEDF)的表达变化;体外培养大鼠肾成纤维细胞(NRK),用RT-PCR检测高糖对VEGF和PEDF mRNA表达的影响.结果 显示糖尿病大鼠肾脏组织VEGF表达增加,而PEDF表达下降.在NRK细胞,高糖呈时间、剂量依赖性地增加VEGF和抑制PEDF的mRNA表达.提示VEGF和PEDF的表达失衡可能在糖尿病肾病的发生发展中起一定作用.
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| 关 键 词： | 血管内皮生长因子 色素上皮衍生因子 糖尿病肾病 成纤维细胞 肾小管间质 |
Effect of the unbalanced expressions of VEGF and PEDF on diabetic nephropathy |
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| LI Jing,LI Zhen-jin,CUI Jing,WANG Shu-e,BAO Yan,YE Ying-chun.Effect of the unbalanced expressions of VEGF and PEDF on diabetic nephropathy[J].Chinese Journal of Endocrinology and Metabolism,2009,25(2). |
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| Authors: | LI Jing LI Zhen-jin CUI Jing WANG Shu-e BAO Yan YE Ying-chun |
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| Abstract: | The expressions of vascular endothelial growth factor(VEGF)and pigment epithelium derived factor(PEDF)in the tubulointerstitium were determined by immunohistochemistry in the streptozotoein-induced diahetic rats.The mRNA expressions of VEGF and PEDF in normal rat kidney (NRK) were measured by using RT-PCR under different high glucose conditions.The results showed that VEGF expression increased and PEDF expression decreased in the kidney tissue of the streptozotocin-induced diabetic rats.Hiish glucose increased VEGF expression and decreased PEDF expression in N RK cells in a time-and dose-dependent manner.The unbalanced expressions of VEGF and PEDF may play an important role in the occurrence and progression of diabetic nephropathy. |
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| Keywords: | Vsscular endothelial growth factor Pigment epithelium derived factor Diabetic nephropathies Fihroblasts Tubulointerstitium |
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