| 脑缺血对局部超氧化物岐化酶、丙二醛水平的影响 |
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| 引用本文： | 周小平,范泽兵,吴芳玲. 脑缺血对局部超氧化物岐化酶、丙二醛水平的影响[J]. 卒中与神经疾病, 1999, 0(1) |
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| 作者姓名： | 周小平 范泽兵 吴芳玲 |
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| 作者单位： | 镇江医学院附属人民医院神经内科 |
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| 摘 要： | 建立大鼠右大脑中动脉栓塞（ＲｉｇｈｔＭｉｄｄｌｅＣｅｒｅｂｒａｌＡｒｔｅｒｙＯｃｌｕｓｉｏｎＲ－ＭＣＡＯ）模型，检测局部缺血后不同时间左右脑组织超氧化物岐化酶（ＳｕｐｅｒｏｘｉｄｅＤｉｓｍｕｔａｓｅＳＯＤ）、丙二醛（ＭＤＡ）的含量，发现Ｒ－ＭＣＡＯ１０分钟始，缺血脑组织ＳＯＤ即降低，至３０分钟后恢复，而ＭＤＡ则在Ｒ－ＭＣＡＯ６０分钟后持续升高。说明缺血后ＳＯＤ活力下降、致ＭＤＡ蓄积，是造成脑组织损伤的机制之一。
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| 关 键 词： | 脑缺血 超氧化物岐化酶 丙二醛 |
The changes of brain tissue SOD and MDA in rats with focal cerebral ischemia |
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| Zhou Xiaoping,Fan Zebing,Wu Fangling People Hospital Affiliated to Zhengjiang Medical College,Jiangsu. The changes of brain tissue SOD and MDA in rats with focal cerebral ischemia[J]. Stroke and Nervous Diseases, 1999, 0(1) |
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| Authors: | Zhou Xiaoping Fan Zebing Wu Fangling People Hospital Affiliated to Zhengjiang Medical College Jiangsu |
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| Affiliation: | Zhou Xiaoping,Fan Zebing,Wu Fangling People Hospital Affiliated to Zhengjiang Medical College,Jiangsu 212002 |
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| Abstract: | SOD and MDA levels of brain tissue in both cerebral hemispheres were measured at different time in rats with right middle cerebral artery occlusion (R MCAO) .Ten minutes after R MCAO SOD activity of the ischemic hemisphere reduced .Thirty minutes late,it recoved.However MDA increased continously after sixty minutes.It was suggested that the mechanism of the damage of focal brain after ischemic injury partly due to SOD resulting MDA accumulation. |
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| Keywords: | Cerebral ischemia SOD MDA |
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