丹参注射液对脑梗死患者异常血脂的调整作用

目的观察丹参注射液对脑梗死患者的血脂影响。方法选取2006年10月～2009年11月河北省赵县人民医院血脂异常的脑梗死患者88例，按治疗方法不同分为治疗组46例及对照组42例，治疗组在常规治疗的基础上给予丹参注射液20mL，1次／d；对照组在常规治疗基础上给予阿托伐他汀钙20mg，1次／d。治疗14d后检测两组患者三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）水平；采用神经功能缺损评分量表（CSS）对两组患者神经功能恢复情况进行评估及比较；比较两组总治疗效果。结果①治疗后两组患者的Tc、TG、LDL—C水平较治疗前均显著下降，而HDL—C水平显著提高，差异均有统计学意义（P〈0．05）；治疗组治疗后HDL—C水平明显高于对照组，差异有统计学意义（P〈0．05），其他指标比较差异无统计学意义（P〉0．05）。②两组患者CSS评分在治疗的第14、28天时，均明显低于治疗前，差异均有统计学意义（P〈0．05），但治疗组第14、28天CSS评分均低于同时间对照组，差异均有统计学意义（P〈0．05）。③治疗组显效39例，有效5例，总有效率为95．6％，对照组显效30例，有效6例，总有效率为85．7％．两组总有效率比较，差异有统计学意义（P〈0．05）。结论血脂异常患者是脑梗死的高危人群，丹参注射液可以调整血脂水平。

Adjustment of Salvia Injection to dyslipidemia on patients with cerebral infarction

Objective To investigate effect of Salvia Injection to dyslipidemia on patients with cerebral infarction. Methods 88 patients with cerebral infarction and dyslipidemia in People＇s Hospital of Zhao County in Hebei Province were selected and divided into 46 cases in treatment group and 42 cases in control group. The treatment group was treated with Salvia Injection 20 mL, 1 time/d on the bases of basic treatment; the control group was treated with Ator- vastatin 20 mg, 1 time/d on the bases of basic treatment. The level of TG, TC, LDL-C, HDL-C in the two groups 14 days after the treatment were detected; the nervous function recovery was evaluated and compared by the CSS scale; the total therapeutic effect was compared between the two groups. Results ①TC, TG, LDL-C level in the two groups after the treatment were all lower than those before the treatment, HDL-C levels in the two groups after the treatment were higher than those before the treatment, the differences were statistically significant （P 〈 0.05）; HDL-C level after the treatment in treatment group was higher than that in the control group, the difference was statistically significant （P 〈 0.05）; the differences of the rest of the indicators were not statistically significant （P 〉 0.05）. ②CSS scores in the two groups 14 and 28 days after the treatment were all lower than those before the treatment, the differences were statisti- cally significant （P 〈 0.05）; CSS scores in treatment group 14 and 28 days after the treatment were all lower than those in control group, the differences were statistically significant （P 〈 0.05）. ③39 cases of excellent, 5 cases of effectivity were found in treatment group, the total effective rate was 95.6%; 30 cases of excellent, 6 cases of effectivity were found in control group, the total effective rate was 85.7%, the difference of the total effective rate between the two groups was statistically significant （P 〈 0.05）. Conclusion Dyslipidemia patients are at high risk of cerebral infarction, Salvia Injection can adjust blood lipid levels.