| 葛花急性毒性及遗传毒性试验研究 |
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| 引用本文： | 关则婷,叶小忠,梁群欢,陈冠敏.葛花急性毒性及遗传毒性试验研究[J].中国医药导报,2014(9):130-134. |
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| 作者姓名： | 关则婷 叶小忠 梁群欢 陈冠敏 |
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| 作者单位： | [1]广东健生堂保健品有限公司,广东广州510600 [2]福建省疾病预防控制中心,福建福州350000 |
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| 基金项目： | 国家高技术研究发展计划（863计划）项目（编号2010AA023001）. |
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| 摘 要： | 目的 研究葛花的急性毒性和遗传毒性.方法 开展葛花对小鼠的急性毒性和遗传毒性实验（Ames、小鼠骨髓嗜多染红细胞微核和小鼠精子畸变试验）,观察葛花的毒理学反应.结果 葛花急性毒性的最大耐受剂量＞ 30g/kg BW,属于无毒级别;Ames试验结果显示为阴性;小鼠骨髓嗜多染红细胞微核实验结果显示为阴性;小鼠精子畸变实验结果为阴性.结论 葛花基本无毒性.
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| 关 键 词： | 葛花 急性毒性试验 遗传毒性试验 |
Experimental study of acute toxicity and genetic toxicity test of pueraria flower |
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| GUAN Zeting,YE Xiaozhong,LIANG Qunhuan,CHEN Guanmin.Experimental study of acute toxicity and genetic toxicity test of pueraria flower[J].China Medical Herald,2014(9):130-134. |
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| Authors: | GUAN Zeting YE Xiaozhong LIANG Qunhuan CHEN Guanmin |
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| Institution: | 1.Guangdong Jianshengtang Health Products Co., Ltd., Guangdong Province, Guangzhou 510600, China; 2.Certre for Disease Control and Prevention of Fujian Province, Fuzhou 350000, China;) |
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| Abstract: | Objective To study the acutetoxicity and genetic toxicity test of pueraria flower.Methods Acute toxicity and genetic toxicity （including Ames test,micronucleus test of bone marrow cells in mice and sperm abnormality test in mice） were tested to observe the toxicological reaction of pueraria flower.Results The MTD of pueraria flower was higher than 30 g/kg BW,belonged to the non-toxic level.Ames test,micronucleus test of bone marrow cells in mice and sperm abnormality test in mice were all negative.Conclusion Puerari＇a flower is non-toxic. |
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| Keywords: | Pueraria flower Acute toxicity test Genetic toxicity test |
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