孟鲁司特钠对哮喘急性发作期患者肺功能及炎症因子的影响

目的探讨孟鲁司特钠对哮喘急性发作期患者的肺功能、外周血炎症因子的影响。方法将2013年1月~2013年6月在琼海市中医院肺病科住院的70例急性发作期哮喘患者作为研究对象,随机分为对照组(予以常规治疗)和治疗组(在对照组治疗基础上加予孟鲁司特钠10 mg,1次/d,睡前服,连续使用2个月)各35例。监测两组患者治疗前后肺功能(FEV1及FEV1/FVC值)、炎症因子(IL-4及IFN-γ)水平值及哮喘控制评分的情况,然后进行对比。结果①治疗后,治疗组肺功能FEV1及FEV1/FVC值均高于对照组,差异有统计学意义(P<0.05)。②治疗后,治疗组患者在外周血IL-4水平值低于对照组,而其IFN-γ水平值高于对照组,差异具有统计学意义(P<0.05)。③治疗后,治疗组哮喘控制评分高于对照组,差异有统计学意义(P<0.05)。结论孟鲁司特钠可以减轻气道炎性反应,起到免疫调节的作用,能有效控制哮喘发作,是疗效确切的哮喘急性发作期辅助药物。

Influence of Montelukast sodium on lung function and inflammatory factor in asthma patients at acute episodes

Objective To discuss the influence of Montelukast sodium on lung function and inflammatory factor in asthma patients at acute episodes. Methods 70 cases of patients at acute episodes of asthma were selected as the research object, in January 2013 to June 2013 at Department of Respiration, Traditional Chinese Medicine Hospital of Qionghai. They were randomly divided into control group（35 cases, given routine treatment） and treatment group（35cases, on the basis of the control group routine treatment, given Montelukast sodium 10 mg, once a day, before sleeping, for 2 consecutive months）. Before and after treatment, both of two groups, the pulmonary function of patients（FEV1and FEV1/FVC）, inflammatory factor（IL-4 and IFN-γ） level and the scores of asthma control were monitored, and then compared. Results ① After treatment, the lung function FEV1and FEV1/FVC value of treatment group were higher than those of control group, the differences were statistically significant（P 0.05）. ②After treatment, the peripheral blood IL-4 level value of treatment group was higher than that of control group, but the IFN-γ level value of treatment group was lower than that of control group, the differences were statistically significant（P 0.05）. ③After treatment,the asthma control score of higher than that of control group, the differences were statistically significant（P 0.05）.Conclusion Montelukast sodium can relieve airway inflammation reaction, adjust immune regulation and control asthma effectively, it is a curative asthma acute phase auxiliary drug.