| 急性早幼粒细胞白血病21例临床分析 |
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| 引用本文： | 张建瑜,唐加明.急性早幼粒细胞白血病21例临床分析[J].国际医药卫生导报,2007,13(12):28-31. |
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| 作者姓名： | 张建瑜 唐加明 |
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| 作者单位： | 广州医学院附属第三医院,广东广州,510150;广州医学院附属第三医院,广东广州,510150 |
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| 摘 要： | 目的 探讨急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)合并出血的临床特点和防治方法.方法 回顾性分析21例APL患者的临床特点及疗效.结果 初诊时合并出血症状20例(95.2%),合并弥漫性血管内凝血(DIC)10例(47.6%),早期死亡5例(23.8%),经全反式维A酸等治疗及血小板及凝血因子输注后完全缓解13例(61.9%).结论 APL出血发生率高,全反式维A酸(ATRA)的应用、血小板及凝血因子输注等治疗可以减少早期出血病死率.
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| 关 键 词： | 急性早幼粒细胞性白血病 全反式维A酸 出血 |
| 文章编号： | 1007-1245（2007）12-0028-03 |
| 修稿时间： | 2007-04-04 |
Clinic Study about 21 Cases of Acute Promyelocytic Leukemia |
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| ZHANG Jianyu,TANG Jiaming.Clinic Study about 21 Cases of Acute Promyelocytic Leukemia[J].International Medicine & Health Guidance News,2007,13(12):28-31. |
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| Authors: | ZHANG Jianyu TANG Jiaming |
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| Institution: | The Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, P.R China, 510150 |
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| Abstract: | Objective To study the clinical features,prevention and treatment of hemorrhage in patients with acute promyelocytic leukemia(APL).Methods The clinical features,laboratory findings and treatment results of 21 cases of APL were analyzed retrospectively.Results 20 cases(95.2%) hemorrhage episodes were observed in the 21 cases of APL,including 13 cases with disseminated intravascular coagulation(DIC). 11(17.5%) early hemorrhagic deaths,13 cases(61.9%) gained complete remission after treatment with chemotherapy and blood compound transfusion. Conclusions Hemorrhage is a common complication in patients with APL. All-trans retinoic acid,transfusion of platelet and coagulation factors could reduce the incidence of early hemorrhagic deaths. |
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| Keywords: | Acute promyelocytic leukemia Hemorrhage All-trans retinoic acid |
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