Novel molecular targeted therapy for esophageal cancer |
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| Authors: | Schrump David S Nguyen Dao M |
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| Affiliation: | Thoracic Oncology Section, Surgery Branch, National Cancer Institute, Bldg. 10, Rm. 4-3490, 10 Center Drive MSC 1201, Bethesda, MD 20892, USA. David_Schrump@nih.gov |
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| Abstract: | Esophageal cancers are highly lethal neoplasms which are generally refractory to conventional multidisciplinary interventions. Recent elucidation of the mechanisms of esophageal carcinogenesis, as well as preclinical studies utilizing chromatin remodeling agents and inhibitors of oncogene signaling in conjunction with conventional chemotherapeutic agents provide new opportunities for the development of potentially efficacious molecular targeted therapies for these malignancies. |
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