赤芍对血液凝固 纤溶系统酶活性的影响

本文研究中药赤芍对凝血—纤溶系统酶活性的影响,以期进一步探讨赤芍活血化瘀作用的机理。实验结果表明,赤芍提取液明显抑制内源、外源凝血系统和凝血酶,能激活纤溶酶原和抑制尿激酶对纤溶酶原的激活作用。结果提示,赤芍抑制凝血酶和激活纤溶酶原是其活血化瘀作用的重要酶学基础。

Effect of Extract of Paeonia lacliflora on the Blood Coagulative and Fibrinolytic Enzymes

Paeonia lactiflora with the action of promoting blood circulation and removing blood stasis had been shown to be able to inhibit thrombosis and platelet aggregation,increase fibrinolytic activity and promote thrombolysis.This paper described the influence of the extract of Paeonia lactiflora in vitro experiments on prothrombin time (PT),activated partial thromboplastin time (PTT),anti- thrombin effect,activity of plasminogen and urokinase.The experimental results showed that:(1) The extract of Paeonia lactiflora prolonged the time of PT and PTT.(2)The extract of drug was able significantly to inhibit the thrombin.(3)In study of fibrinolysis by fibrin standard plate experiments, the drug possessed activative effect on the plasminogen.(4)The activity of urokinase was reduced, while the extract of Paeonia lactiflora existed.The inhibitory effect on thrombin and effective effect on plasminogen of the drug might be an important mechanism of its action of promoting blood circulation and removing blood stasis.