瘦素在胰岛素增敏剂治疗多囊卵巢综合征中的相关研究

目的:观察胰岛素增敏剂罗格列酮治疗前后肥胖和非肥胖的多囊卵巢综合征(PCOS)患者瘦素水平的变化情况.方法:73例PCOS患者分为肥胖组(43例)和非肥胖组(30例).观察罗格列酮治疗前后瘦素水平及相关指标的变化.结果:PCOS组瘦素水平明显高于对照组,治疗前后肥胖组的瘦素水平均高于非肥胖组,PCOS肥胖组治疗后瘦素水平明显下降(P＜0.01),非肥胖组治疗后瘦素水平也有下降(P＜0.05).相关性分析显示血清瘦素水平与体重指数(BBI)呈正相关(P=0.007),与空腹胰岛素(FINS)、LH呈正相关(P=0.028、P=0.041),与高胰岛素正葡萄糖钳夹试验(HGCT)有负相关性(P=0.015).结论:血清瘦素水平是胰岛素增敏剂治疗有效的指标之一.

Significance of Leptin in assessment of insulin-sensitizing agent therapy for PCOS and correlation analysis

Objective:To investigate the indicative value of the serum leptin level in obesity and non-obesity PCOS patients treated with insulin-sensitizing agent rosiglitazone.Methods:73 PCOS patients were divided into obesity(43)and non-obesity group(30).The changes of the serum leptin level and the relevant indexes were observed before and after treament with rosiglitazone.Results:the leptin level of PCOS groups was higher than that in control and the level in obesity PCOS patients was higher than that in non-obesity PCOS patients both before and after treatment.After treatment,the leptin levels in both PCOS groups were all significantly decreased,greater decrease in obesity group.Correlation:analysis revealed that the leptin level had positive correlation with BMI,FINS and LH,but negative correlation with the HGCT.Conclusion serum leptin level has some indicative value in the assessment of insulin-sensitizing agent in treating PCOS.