逍遥滴鼻液对实验性偏头痛模型大鼠行为症状的影响

目的研究逍遥滴鼻液通过鼻腔给药对实验性偏头痛模型大鼠行为症状的影响。方法将50只Wistar大鼠随机分为5组：正常对照组、模型组、太极通天口服液灌胃组、逍遥滴鼻液灌胃组及逍遥滴鼻液滴鼻组。根据Cristina Tassorelli报道的方法加以改进，造模成功后分别给予相应观察药物，采用时间分段计数法持续观察给药后大鼠行为症状变化。结果逍遥滴鼻液滴鼻组大鼠症状的改善显著优于逍遥滴鼻液灌胃组和太极通天口服液灌胃组。结论逍遥滴鼻液可显著改善模型大鼠的偏头痛症状。

The Effects of Xiaoyao Nose Dripping Liquid on Behavior and Symptoms of Experimental Rat Migraine Model

Objective To investigate the effects of Xiaoyao nose dripping liquid on the behavior and symptoms of experimental rat migraine model. Methods Fifty Wistar rats were randomly divided into 5 groups, each of 10 rats: normal control, model group, taijitongtiankoufuye liquid given orally group, Xiaoyao nose dripping liquid given orally group and Xiaoyao nose dripping liquid dripped into nose group. The experimental migraine model rats were duplicated by modified method reported by Tassorelli. The created rat models were given corresponding drugs and their changes of behaviors and symptoms were continuously observed at various time intervals. Result The symptom amelioration by Xiaoyao nose dripping liquid dripped into nose group was significantly better than Xiaoyao nose dripping liquid and taijitongtiankoufuye taken orally groups. Conclusion Xiaoyao nose dripping liquid may significantly improve the symptoms of migraine.