TT病毒国内外研究进展

TTV是 1997年由日本学者真弓忠发现的一种新病毒 ,被认为是一种有可能引起输血后肝炎的新的DNA病毒 ,称输血传播病毒 ,也称TT病毒。本文介绍了TTV的发现、自然史追踪、病原学、检测、致病性、传播途径、病理表现和在非甲 -庚型肝炎患者中的检出率。众多的研究结果表明 ,它可能是导致非甲 庚型肝炎的重要病原。有些研究还认为 ,TTV可能是导致肝炎慢性化的病原之一 ,也是导致爆发型肝炎或肝衰竭的重要因素之一。但仍有一些研究者认为 ,TTV感染不一定致病 ,其致病性尚待进一步研究证实。现已证实 ,TTV还存在非血液传播的途径 ,肠道传播是重要的 ,我国已证实有肠道传播型TTV引起的集体病毒性肝炎流行。

Advance on TT Virus at Home and Abroad

A new DNA virus was detected from the serum of a Non-A to G hepatitis patient by a Japanese scholar Nishizawa in December 1997.It is a new DNA virus which might be hepatopathogenic and might be a pathogen of post-transfusion hepatits.The new virus was named transfusion transmitted virus,and also was named TT virus.The detection,track of natural history,physicochemical characteristics,genotype,pathogenicity,pathogenic feature,route of transmission and the detected rate in non-A to G hepatitis of the virus was introduced in the paper.The results of many researches indicated that the virus is possibly an important pathogen of Non-A to G hepatitis.Some researchers also hold that the TT virus is possibly one of the pathogen led to chronic hepatitis,and one of the significant factors led to fulminant hepatitis or hepatic failure.Nevertheless,many researchers still considered that the pathogenicity of TT virus is uncertain and still remain to be confirmed after further studies.It has been confirmed that TT virus still existed non-blood route of transission.Entero-transmission of TT virus is important.A collective viral hepatitis epidemic evoked by entero-transmitted TT virus was verified in China.