氨苄西林和左氧氟沙星对肠球菌属联合用药的试验研究

目的对氨苄西林和左氧氟沙星对肠球菌属联合用药的体外试验进行研究,为临床联合用药治疗肠球菌属严重感染提供试验依据。方法全部106株肠球菌属菌株经VITEK-2Compact鉴定,同时对其进行氨苄西林和左氧氟沙星最低抑菌浓度(MIC)测定和两种药物棋盘微量稀释法联合药敏试验;选取4株肠球菌属菌株进行左氧氟沙星和氨苄西林体外时间-杀菌曲线试验。结果 106株肠球菌属菌株对氨苄西林、左氧氟沙星的总耐药率分别为82.1%、57.5%;粪肠球菌和屎肠球菌对氨苄西林的耐药率分别为75.4%、91.1%,对左氧氟沙星的耐药率分别为49.2%、68.9%,氨苄西林和左氧氟沙星联合对106株肠球菌属菌株中有协同、累加、无关作用的分别为23.6%、15.1%、61.3%。结论肠球菌属对氨苄西林有很高的耐药率,且屎肠球菌高于粪肠球菌;左氧氟沙星和氨苄西林是否存在协同作用取决于两者各自对肠球菌属的MIC。

Combination of Ampicillin and Levofloxacin Against Enterococci

OBJECTIVE To study the combination activity of ampicillin and levofloxacin against enterococci by the checkboard dilution,to provided experimental basis for treating the seriously-ill patients infected by Enterococci.METHODS A total of 106 enterococci strains were identified with VITEK-2 Compact.MICs of ampicillin and levofloxacin for 106 enterococci strains were tested,at the same time.The combination activity test for ampicillin and levofloxacin against 106 strains enterococci were performed by the checkb...