Overproduction of Cyclin D1 is dependent on activated mTORC1 signal in nasopharyngeal carcinoma: Implication for therapy |
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| Authors: | Xiao-ming Huang Cheng-bo Dai Zhong-lin Mou Li-juan Wang Wei-ping Wen Shu-guang Lin Geng Xu Hua-bin Li |
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| Affiliation: | 1. Allergy and Cancer Center, Otorhinolaryngology Hospital of The First Affiliated Hospital of Sun Yat-sen University and Otorhinolaryngology Institute of Sun Yat-sen University, Guangzhou 510080, China;2. Department of Otolaryngology, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China;3. Research Center of Medical Sciences, Guangdong General Hospital, and Guangdong Academy of Medical Sciences, Guangzhou 510080, China;4. Department of Otolaryngology, Hainan Provincial Hospital, Haikou 570220, China |
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| Abstract: | Activated mTOR was implicated to play a role in the carcinogenesis of nasopharyngeal carcinoma (NPC). However, the mechanism of activated mTOR/Complex1(mTORC1) signaling pathway in NPC development has not been well established. In this study, we correlated the expression of mTORC1 signal molecules and Cyclin D1 in NPC. We also investigated the effect of blocking mTORC1 signal with rapamycin and mTOR siRNA on Cyclin D1 expression in CNE-2 cells, as well as cell apoptosis and viability. We found a positive association of mTORC1 signal molecules and Cyclin D1 in NPC. Also, we found blockage mTORC1 inhibited Cyclin D1 expression in CNE-2 cells and enhanced cell apoptosis. Our results suggested that mTORC1 signal pathway might be a potential target for NPC therapy. |
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| Keywords: | mTORC1 Cyclin D1 Apoptosis Therapy Nasopharyngeal carcinoma |
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