Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer |
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| Authors: | Zhenbo Zhang Lin Jia Youji Feng Wenxin Zheng |
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| Affiliation: | 1. Hospital of Obstetrics and Gynecology, Shanghai Medical College Fudan University, 379 Fang Xie Road, Shanghai 200011, China;2. Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, China;3. Department of Pathology, University of Arizona College of Medicine, 1501 N. Cambell Avenue, Tucson, AZ 85724, USA;4. Department of Obstetrics and Gynecology, University of Arizona College of Medicine, Tucson, AZ, USA;5. Arizona Cancer Center, University of Arizona, Tucson, AZ, USA |
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| Abstract: | We previously showed that the expressing level of FSH receptor (FSHR) increased from ovarian epithelial inclusions (OEIs) to benign ovarian epithelial tumors (OETs) and to borderline OETs, whereas FSHR levels decreased with an increase in carcinoma grade. The aim of this study was to investigate the role of FSHR in OET development. MCV152 cells with FSHR overexpression showed an increased cellular proliferation and invasive capacity, which was associated with reduced levels of prohibitin and RII-β expression and increased levels of HER-2/neu, c-Myc, and EGFR expression. Overexpression of FSHR may be associated with an elevated level of OET cell proliferation via an enhanced activity of potential oncogenic pathways. Therefore, the findings in this study suggest that overexpression of FSHR may play a role in OET development. |
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| Keywords: | FSH, follicle-stimulating hormone FSHR, follicle-stimulating hormone receptor OEC, ovarian epithelial cancer OET, ovarian epithelial tumor OSE, ovarian surface epithelium OEI, ovarian epithelial inclusion |
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