CXCR4 mediates the proliferation of glioblastoma progenitor cells |
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Authors: | Moneeb Ehtesham Khubaib Y Mapara Charles B Stevenson Reid C Thompson |
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Institution: | 1. Department of Neurological Surgery, Vanderbilt University Medical Center, 21st Avenue & Garland Street, Nashville, TN 37232, USA;2. Department of Cancer Biology, Vanderbilt University Medical Center, 21st Avenue & Garland Street, Nashville, TN 37232, USA;3. The Vanderbilt Ingram Cancer Center, 21st Avenue & Garland Street, Nashville, TN 37232, USA |
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Abstract: | Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. To this end, we now report that the cell surface chemokine receptor, CXCR4, a known mediator of cancer cell proliferation and invasion, is overexpressed in primary glioblastoma progenitor cells versus corresponding differentiated tumor cells. Furthermore, administration of CXCL12, the only known ligand for CXCR4, stimulates a specific and significant proliferative response in progenitors but not differentiated tumor cells. Taken together, these results implicate an important role for the CXCR4 signaling mechanism in glioma CSC biology and point to the therapeutic potential of targeting this pathway in patients with GBM. |
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Keywords: | GBM glioblastoma multiforme GDS glioma-derived spheres CSC cancer stem cells |
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