Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7 |
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| Authors: | Sunyoung Park Sun Young Yoon Kyung-Eun Kim Ha Reum Lee Dae Young Hur Hyunkeun Song Daejin Kim Sa Ik Bang Dae-Ho Cho |
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| Affiliation: | 1. Department of Life Science, Sookmyung Women’s University, Seoul, Republic of Korea;2. Department of Anatomy and Research Center for Women’s Disease, Inje University Busan Paik Hospital, Busan, Republic of Korea;3. Department of Anatomy, College of Medicine, Chung Ang University, Seoul, Republic of Korea;4. Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea |
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| Abstract: | Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells. |
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| Keywords: | Interleukin-18 (IL-18) Transferrin Proliferation Breast cancer |
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