| 人工神经网络在 Horn's法LD50试验中的应用 |
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| 引用本文： | 陈小玉,徐力平.人工神经网络在 Horn''s法LD50试验中的应用[J].郑州大学学报(医学版),2003,38(4):554-557. |
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| 作者姓名： | 陈小玉 徐力平 |
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| 作者单位： | 1. 郑州大学公共卫生学院劳动卫生与职业病学教研室,郑州,450052
2. 郑州大学信息工程学院电子工程系,郑州,450052 |
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| 摘 要： | 目的：探索LD50计算方法新思路。方法：以4组动物的死亡数和给药剂量作为输入量，用神经网络计算LD50,并对神经网络的隐层节点数进行选择，以提高计算精度。结果：对急性毒作用带较宽的化学物质，应用人工神经网络方法计算其LD50能客观地反映实际情况，且节省人力和动物。结论：人工神经网络方法计算结果可以对Horn’s法LD50结果加以补充。
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| 关 键 词： | 人工神经网络 Horn’s法 LD50试验 应用 半数致死剂量 隐层单元 |
| 修稿时间： | 2002年11月15 |
Application of artificial neural networks in LD50 test using Horn's method |
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| CHEN Xiaoyu ,XU Liping Departemnt of Industrial Hygiene and Occupational Diseases,College of Public Health,Zhengzhou University,Zhengzhou.Application of artificial neural networks in LD50 test using Horn''''s method[J].Journal of Zhengzhou University: Med Sci,2003,38(4):554-557. |
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| Authors: | CHEN Xiaoyu XU Liping Departemnt of Industrial Hygiene and Occupational Diseases College of Public Health Zhengzhou University Zhengzhou |
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| Institution: | CHEN Xiaoyu 1),XU Liping 2) 1)Departemnt of Industrial Hygiene and Occupational Diseases,College of Public Health,Zhengzhou University,Zhengzhou 450052 2)Department of Electronic Engineering,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim:To study a new idea of computing LD 50 for practical application.Methods: LD 50 was computed by artificial neural networks with the number of died animals in 4 groups and the given doses as inputs. In order to improve the accuracy, the number of the hidden units of the neural networks was selected.Results: Computing LD 50 by artificial neural networks was practical for the chemical material with broad acute toxic zone.Conclusion: The results of computing with neural networks can be a supplement for the Horn'method. |
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| Keywords: | LD 50 neural network hidden unit |
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