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No evidence for association between <Emphasis Type="Italic">tau</Emphasis>gene haplotypic variants and susceptibility to Creutzfeldt-Jakob disease |
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| Authors: | Pascual Sánchez-Juan Matthew T Bishop Alison Green Claudia Giannattasio Alejandro Arias-Vasquez Anna Poleggi Richard SG Knight Cornelia M van Duijn |
| Institution: | 1.Institute for Formation and Research of the Fundación "Marqués de Valdecilla" (IFIMAV),Santander,Spain;2.Genetic Epidemiology Unit,Epidemiology & Biostatistics department, Erasmus MC,Rotterdam,The Netherlands;3.Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED),Italy;4.National CJD Surveillance Unit,The University of Edinburgh,Edinburgh,UK;5.Istituto Superiore di Sanità,Laboratory of Virology, Viale Regina Elena 299,Rome,Italy |
| Abstract: | BackgroundA polymorphism at codon 129 of the prion protein gene (PRNP) is the only well-known genetic risk factor for Creutzfeldt-Jakob disease (CJD). However, there is increasing evidence that other loci outside the PRNP open reading frame might play a role in CJD aetiology as well. |
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