HER-2, p53, p21 and hormonal receptors proteins expression as predictive factors of response and prognosis in locally advanced breast cancer treated with neoadjuvant docetaxel plus epirubicin combination |
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| Authors: | Daniel G Tiezzi Jurandyr M Andrade Alfredo Ribeiro-Silva Fábio E Zola Heitor RC Marana Marcelo G Tiezzi |
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| Affiliation: | 1.Department of Gynecology and Obstetrics – Breast Disease Division – Ribeirao Preto School of Medicine – HCFMRP- USP,Ribeir?o Preto,Brazil;2.Department of Pathology – Ribeirao Preto School of Medicine – HCFMRP- USP,Ribeirao Preto,Brazil;3.Colaborating Pathologist from Presidente Prudente Laboratory of Pathology and Cytopathology, S/A,Presidente Prudente,Brazil |
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| Abstract: | Background Neoadjuvant chemotherapy has been considered the standard care in locally advanced breast cancer. However, about 20% of the patients do not benefit from this clinical treatment and, predictive factors of response were not defined yet. This study was designed to evaluate the importance of biological markers to predict response and prognosis in stage II and III breast cancer patients treated with taxane and anthracycline combination as neoadjuvant setting. |
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