地塞米松对重症急性胰腺炎大鼠多脏器损伤的保护作用

目的观察地塞米松对重症急性胰腺炎多脏器（胰腺、肺、肾、肝）损伤大鼠的保护作用。方法采用改良Aho法制备SAP大鼠模型，设模型组、地塞米松治疗组、假手术组。各组分别于术后3h，6h，12h观察存活率，多脏器大体及光镜下病理变化。结果模型组和地塞米松治疗组在各时点存活率无明显差异（P〉0．05）。多脏器病理评分不同时间点模型组和治疗组均明显大于假手术组（P〈0.001，P〈0．05），治疗组不同程度小于模型组（P〈0.05，P〈0．01）。结论地塞米松能够减轻SAP大鼠胰腺、肺、肾及肝脏的损伤，对SAP大鼠多脏器损伤具有保护作用。

Study of the Protecting effects of Dexamethasone on Multiple Organ Injury in Rats with Severe Acute Pancreatitis

Objective To observe the protecting effects of dexamethasone on multiple organs (pancreas, lung, kidney and liver) in Rats with Severe Acute Pancreatitis. Methods Prepared 90 SD rats SAP models and randomly divided them into the model group , dexamethasone treatment group and sham operation group. The survivals, gross changes and pathological changes of multiple organs under light microscope of each group were observed at 3h, 6h and 12h after operation.Results (1) There was no obvious difference between the model group and dexamethasone treatment group in survival at all time points (P<0.05).(2)Comparison of multiple organs pathological scores showed: both the model group and dexamethasone treatment group obviously exceeded the sham operation group at different time points (P<0.001,P<0.05); the treatment group was obviously lower than the model group at different time points (P<0.05,P<0.01). Conclusions Dexamethasone can alleviate the pancreas, lung, kidney and liver injury of SAP rats and has protecting effects on multiple organ injury of SAP rats.