| 痛风平对实验性急性痛风性关节炎抗炎消肿镇痛作用的研究 |
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| 引用本文： | 姜宏,惠祁华,陈咏真,曹莉. 痛风平对实验性急性痛风性关节炎抗炎消肿镇痛作用的研究[J]. 中国中医药信息杂志, 2005, 12(3): 30-32 |
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| 作者姓名： | 姜宏 惠祁华 陈咏真 曹莉 |
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| 作者单位： | 1. 苏州市中医医院,江苏,苏州,215003
2. 苏州大学药学系,江苏,苏州,215000 |
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| 摘 要： | 目的探讨痛风平对兔急性痛风性关节炎的药物作用。方法用微晶型尿酸钠(MSU)给兔关节腔内注射,造成兔急性痛风性关节炎模型,观察痛风平(中药组)、秋水仙碱(阳性药组)、模型组及正常组关节滑膜的病理改变。结果痛风平可明显减少关节滑膜中炎性细胞浸润,减轻急性痛风性关节炎造成的兔关节滑膜的充血、肿胀和坏死。结论痛风平可减轻兔急性痛风性关节炎的炎症反应,减轻由此引起的关节滑膜的病理改变。
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| 关 键 词： | 痛风平 急性痛风性关节炎 滑膜 病理 兔 |
| 文章编号： | 1005-5304(2005)03-0030-03 |
| 修稿时间： | 2004-11-30 |
Study of Tongfengping on Pathological Changes of Synovial Membrane in Rabbit Experimental Acute Goute Arthritis |
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| JIANG Hong,HUI Qi-hua,CHEN Yong-zhen,et al. Study of Tongfengping on Pathological Changes of Synovial Membrane in Rabbit Experimental Acute Goute Arthritis[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2005, 12(3): 30-32 |
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| Authors: | JIANG Hong HUI Qi-hua CHEN Yong-zhen et al |
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| Abstract: | Objective To investigate the pharmacologic effect of Tongfengping on rabbit acute goute arthritis. Methods The rabbit acute goute arthritis model was made by injecting monosodium urate to rat joint cavity. The rats were divided into four groups which include Tongfengping group (Chinese Medicine group), colehicine group (positive drug group), model group and normal control group. The changes of joint synovial membrane were individually observed. Results Tongfengping can significantly reduce inflammatory cell infiltration. It also can relieve congestion, swelling and necrosis of rabbit joint synovial membrane caused by acute goute arthritis. Conclusions Tongfengping can reduce the inflammatory reaction caused by rabbit acute gouty arthritis and pathological changes of joint synovial membrane. |
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| Keywords: | Tongfengping acute gouty arthritis synovial menbrane pathology rabbit |
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