木豆叶、福善美、钙尔奇D和骨松宝治疗绝经后骨密度降低的疗效观察

目的探讨木豆叶等中药和福善美、骨松宝治疗绝经后骨密度降低的疗效。方法将78例绝经后骨量减少和骨质疏松女性患者随机分为A组(38例),B组(40例)。A组服用福善美、钙尔奇D、骨松宝;B组服用福善美、钙尔奇D、骨松宝加木豆叶等中药。A、B组均服药6个月,观察两组治疗前后骨密度(BMD),雌二醇(E26 III),骨钙素(OCN)值的变化。结果A组与B组治疗前后的BMD值均差异显著(p<0.01);E26 III均有差异(p<0.05);OCN亦有差异(p<0.01;p<0.05)。A与B组之间的疗效比较治疗前后BMD、E26 III、OCN均无差异(p>0.05)。结论福善美、骨松宝、钙尔奇D联合治疗绝经后骨密度降低患者(骨量减少,骨质疏松)有明显疗效,E26 III水平升高,BMD和OCN水平降低。

CLINICAL OBSERVATION OF PIGEON PEA LEAVES,FOSAMAX,CALTRATE D AND GUSONGBAO COMBINATION TREATMENT IN POSTMENOPAUSAL LOWER BONE MINERAL DENSITY

Objective Studying the treating effect on postmenopausal lower bone mineral density by using traditional Chinese medicine （ pigeon pea leaves, etc. ）, with Fosamax and Gusongbao. Methods Randomly divide 78 cases of female patients with postmenopausal lower bone mineral density and osteoporosis into Group A （38 cases） and Group B （40 cases）. Group A was given Fosamax,Caltrate D and Gusongbao; Group B was given Fosamax,Caltrate D, and Gusongbao plus Chinese medicine （ pigeon pea leaves, etc. ）. Both Group A ＆ B take their own medicines for six months ,then observe the changes of bone mineral density （BMD） ,estradiol （E26Ⅲ） and osteocalcin （OCN） in these two Groups before and after the treatment. Results The BMD values before and after treatment were significantly different （p 〈0. 01） in Group A and Group B; E26Ⅲ have differences （p 〈0. 05） ; OCN also differences （p 〈 0. 01 ; p 〈 0.05）. By comparing between Group A and B, the BMD, E26Ⅲ and OCN before and after treatment have no differences （p 〉 0.05）. Conclusion Effect of the combine treatment of Fosamax, Gusongbao and Caltrate - D in postmenopausal lower bone mineral density patients （ reduction of bone mineral density, osteoporosis） is significant with E26Ⅲ level rises, and BMD, OCN level decreases.