电针不同经穴对急性心肌缺血家兔心功能的影响

目的:探讨不同经穴的相对特异性作用。方法:60只家兔分为正常对照组、模型对照组、电针内关组、电针太渊组、电针神门组、电针支正组和电针三阴交组,采用静脉注射脑垂体后叶素复制急性心肌缺血模型,记录标准导联Ⅱ导心电图,获取心率、左室内压最大上升速率和下降速率以及左心室收缩压力峰值,比较电针不同经穴对急性心肌缺血家兔心功能的影响。结果:心肌缺血后,心功能各项指标值的绝对值均显著降低。电针内关组、电针神门组和电针支正组对心功能改善作用明显优于电针太渊组和电针三阴交组(P<0.05),且与模型组比较差异有显著性意义(P<0.05)。电针内关组和电针神门组与电针支正组比较差异有显著性意义(P<0.05)。结论:电针"内关"神门"和"支正"穴可显著改善急性心肌缺血家兔的心功能,且"内关"和"神门"穴的效应更明显。而电针"太渊"穴和"三阴交"穴对心功能的改善无明显作用。

Effects of Electroacupuncture of Different Acupoints on Cardiac Function in Acute Myocardial Ischemia Rabbits

OBJECTIVE: To observe the effects of electroacupuncture (EA) of "Neiguan" (PC 6), "Shenmen" (HT 7), "Taiyuan" (LU 9), "Zhizheng" (SI 7) and "Sanyinjiao" (SP 6) on cardiac function in acute myocardial ischemia (AMI) rabbits. METHODS: A total of 60 rabbits were randomly divided into normal control, model, EA-PC6, EA-HT7, EA-LU9, EA-S17 and EA-SP6 groups. AMI model was established by intravenous administration of pituitrin. ECG, maximal ascending rate ( + dp/dt max) and maximal descending rate (- dp/dt max) of the left ventricular pressure, and left ventricular systolic pressure (LVSP) were recorded. RESULTS: The heart rate (HR), +dp/dt max, -dp/dt max and LVSP decreased significantly after AMI (P<0.01). Compared with model group, the 4 indexes of EA-PC6, EA-HT7 and EA-S17 groups increased considerably (P<0.05, 0.01) at most time-points after AMI, and the effects of EA-PC6 and EA-HT7 were markedly better than those of EA-SI7, EA-LU9 and EA-SP6 (P<0.05, 0.01). No significant differences were found among model group, EA-LU9 and EA-SP6 groups in HR, + dp/dt max, -dp/dt max and LVSP at most time-points after AMI. CONCLUSION: EA of PC6, HT7 and SI7 has a good effect in improving ischemic cardiac performance, and the effect of PC6 and HT7 is markedly better than that of SI7. The effect of EA of SP6 and LU9 is poorer on ischemic cardiac function.