In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus |
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Authors: | Sun Chunguang Falagas Matthew E Wang Rui Karageorgopoulos Drosos E Yu Xuhong Liu Youning Cai Yun Liang Beibei Song Xiujie Liu Zheyuan |
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Affiliation: | Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, China. |
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Abstract: | This study aimed to evaluate the in vitro activity of minocycline combined with fosfomycin against isolates of methicillin-resistant Staphylococcus aureus (MRSA). A total of 87 clinical isolates of MRSA collected from three Chinese hospitals were included in the study. The checkerboard method with determination of the fractional IC index (FICI) was used to determine whether antibiotic combinations act synergistically against these isolates. The susceptibility results for minocycline and fosfomycin were interpreted according to the most relevant criteria. The results demonstrated the following interactions: 76 isolates (87.4%) showed synergistic interactions (FICI0.5) and 11 isolates (12.6%) showed indifferent interactions (0.5
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