2型糖尿病血糖控制对血脂影响

目的 探讨2型糖尿病血糖控制对于血脂的影响。方法 对79例2型糖尿病患者在血糖控制前后进行血糖、血脂检测,并与58名体检健康人员的血糖、血脂进行对比分析。RT-PCR法检测载脂蛋白B(APOB)基因的表达。结果 2型糖尿病患者与正常对照组比较,糖化血红蛋白(HbA1c)、甘油三酯(TG)、血清总胆固醇(TC)和低密度脂蛋白(LDL-C)显著增高;2型糖尿病患者经胰岛素治疗后,HbA1c、TG、TC和LDL-C显著降低。患病组APOB基因的表达要高于正常组,在治疗后,APOB基因表达降低,但仍高于正常组。结论 控制2型糖尿病患者的血糖水平,可以部分改善血脂异常。

Effect of blood glucose control of type 2 diabetes on serum lipid

Objective To study the effect of blood glucose control of type 2 diabetes on serum lipid.Methods 58 normal controls and 79 patients with type 2 diabetes were enrolled,and the levels of blood lipid(TG,TC and HDL,LDL),serum insulin and HbA1c were measured.To detect the expression of APOB gene by RT-PCR.Results The levels of HbA1c,TG,TC,LDL in patients with type 2 diabetes were significantly increased.By insulin therapy,the levels of HbA1c,T G,TC,LDL in patients were decreased.The expression of APOB gene in patients were higher than normal controls.By therapy,the expression of APOB gene were decreased,but were higher than the normals.Conclusion Control the levels of blood glucose of patients with type 2 diabetes could have a better lipid profile.