冠心病患者血清可溶性P-选择素、高敏C反应蛋白及血脂检测

目的:探讨冠心病患者血清可溶性P-选择素(Ps)、高敏C反应蛋白(hs-CRP)和血脂水平的变化.方法:检测25例急性心肌梗死(AMI组)患者,31例不稳定心绞痛(UAP组)患者,22例稳定型心绞痛(SAP组)患者和20例冠脉造影排除冠心病者(对照组)的血清Ps、hs-CRP和血脂(包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C))水平.结果:AMI组、UAP组和对照组Ps和hs-CRP水平两两比较差异有统计学意义(P＜0.05),而在SAP组和对照组差异无统计学意义(P＞0.05);冠心病患者TC、LDL-C与Ps、hs-CRP呈显著正相关(P＜0.05).结论:①AMI组和UAP组Ps和hs-CRP明显升高,是冠心病诊断的有用指标.②冠心病患者的TC、LDL-C可能有刺激血管炎症反应、激活血小板的作用.

Correlation between serum soluble P-selectin, high sensitive C-reactive protein and lipids in patients with coronary heart diseases

Aim: To study the correlations between the serum soluble P-selectin (sP-selectin), high sensitive C-reactive protein (hs-CRP) and lipids in patients with coronary heart diseases (CHD).Methods:The levels of sP-selectin, hs-CRP, TC, TG, HDL-C and LDL-C were measured in 25 patients with acute myocardial infarction (group AMI), 31 patients with unstable angina pectoris (group UAP), 22 patients with stable angina pectoris (group SAP), and 20 controls.Results: sP-selectin and hs-CRP in group AMI and group UAP were significantly higher than those in group SAP and the controls,however, sP-selectin and hs-CRP were similar in group SAP and the controls. There were obvious positive correlations between TC, LDL-C and sP-selectin and hs-CRP levels in patients with CHD.Conclusion: P-selectin and hs-CRP are useful markers in the diagnosis and classification of CHD. TC and LDL-C may aggravate the systemic inflammation and activate platelet in patients with CHD.