Suppression of phagocytosis in immunized animals |
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| Authors: | A. A. Pal'tsyn E. G. Kolokol'chikova A. K. Badikova N. V. Chervonskaya I. A. Grishina |
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| Affiliation: | (1) Department of Pathological Anatomy, Laboratory of Prevention and Treatment of Bacterial Infections, A. V. Vishnevskii Institute of Surgery, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | It is found that phagocytosis in animals immunized withPseudomonas aeruginosa, Staphylococcus aureus, andStaphylococcus epidermidis is suppressed in comparison with intact animals, and the degree of suppression rises with the antibody titer. Morphological study of the site of infection shows that antibodies markedly enhance bacteriopyknosis, i.e., convert bacteria into nonphagocytizable detritus. Focal suppression of phagocytosis in immunized animals is attributed to rapid bacteriopyknosis and, consequently, to a sharp decrease in the number of intact bacteria that can be digested by phagocytes. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 348–352, September, 1996 |
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| Keywords: | infectious immunity antibodies phagocytosis nonspecific organism's resistance |
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