| 高敏C反应蛋白和脂蛋白(a)联合检测在冠心病诊断中的应用 |
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| 引用本文： | 刘勇,闾宏伟,李丽军.高敏C反应蛋白和脂蛋白(a)联合检测在冠心病诊断中的应用[J].中国现代医学杂志,2006,16(6):904-906. |
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| 作者姓名： | 刘勇 闾宏伟 李丽军 |
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| 作者单位： | 1. 中南大学生物医学工程研究院,湖南,长沙,410008
2. 中南大学湘雅三医院,实验中心,湖南,长沙,410013 |
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| 基金项目： | 湖南省科技计划;浙江省湖州市自然科学基金;湖南省卫生厅科研项目;湖南省科技计划 |
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| 摘 要： | 目的 探讨高敏C反应蛋白（hs-CRP）和脂蛋白（a）联合检测对冠心病的诊断价值。方法 对166例疑诊冠心病的患者进行冠状动脉造影检查，根据造影结果分为冠心病组（CHD组）和非冠心病组（非CHD组），并分别进行hs-CRP和Lp（a）的测定、分析。结果 CHD组患者血浆hs-CRP和Lp（a）浓度均高于非CHD组（P〈0．01）。两项指标联合检测对CHD患者诊断的特异度（89．2％）高于分别应用hs-CRP（86．5％）或Lp（a）（70.3％）单一指标。结论 hs-CRP和Lp（a）两项指标联合检测更有助于冠心病的预测和论断．
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| 关 键 词： | 高敏C反应蛋白 脂蛋白a 冠心病/诊断 |
| 文章编号： | 1005-8982（2006）06-0904-03 |
| 收稿时间： | 2006-01-02 |
| 修稿时间： | 2006-01-02 |
Value of plasma high-sensitivity C-reactive protein and lipoprotein (a) in diagnosis of coronary heart disease |
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| LIU Yong,LV Hong-wei,LI Li-jun.Value of plasma high-sensitivity C-reactive protein and lipoprotein (a) in diagnosis of coronary heart disease[J].China Journal of Modern Medicine,2006,16(6):904-906. |
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| Authors: | LIU Yong LV Hong-wei LI Li-jun |
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| Institution: | 1. Institute of Biomedical Engineering, Central South University, Changsha, Hunan 410008, P.R.China; 2. Center for Medical Research, the Third Xiangya Hospital Central South University, Changsha, Hunan 410013, P.R.China |
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| Abstract: | Objective] To study the value of detecting plasma high-sensitivity C-reactive protein (hs-CRP) and lipoprotein(a) (Lp(a)) in the diagnosis of coronary heart disease(CHD). Methods] 166 suspected cases of CHD undergone coronary arteriongraphy were classified into CHD group and non-CHD group. hs-CRP and Lp(a) were evaluated and analyzed in both of these two groups. Results] The concentration of hs-CRP and Lp(a) were significantly higher in CHD patients than that in the non-CHD subjects(P <0.01). The specificity of detecting all the three markers (0.919) was higher than that of single marker detecetion of either Lp(a) (0.703) or Fig (0.757) or hs-CRP(0.865). Conclusion] Combined detection of two markers of hs-CRP and Lp(a) may help improve the diagnosis of CHD. |
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| Keywords: | high-sensitivity C-reactive protein lipoprotein(a) coronary heart disease/diagnosis |
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