| 糖尿病大鼠钙调节激素的变化 |
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| 引用本文： | 陈为,杨岚,陈伟,朱明双. 糖尿病大鼠钙调节激素的变化[J]. 海南医学院学报, 2002, 8(3): 134-135,138 |
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| 作者姓名： | 陈为 杨岚 陈伟 朱明双 |
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| 作者单位： | 1. 四川成都中医药大学 基础医学院中医诊断学研究室，成都 610072
2. 四川成都中医药大学 临床医学院骨科，成都 610072 |
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| 摘 要： | 目的:探讨糖尿病(DM)大鼠钙调节激素的变化。方法:测定实验性糖尿病大鼠及自由择食大鼠空腹血糖、胰岛素(Ins)、骨密度、骨钙素、降钙素、甲状旁腺激素(PTH)和维生素D3。结果:糖尿病大鼠与正常对照组相比,骨密度明显降低(P<0.01),骨钙素(BGP)水平有升高趋势,但无显著性差异(P>0.05),降钙素水平、维生素D3显著降低(P均<0.01),PTH显著升高(P<0.01)。结论:糖尿病状态下存在骨量减少、钙调节激素异常,主要表现为骨密度明显降低,甲状旁腺激素升高,维生素D3及降钙素水平降低。糖尿病骨质疏松可能与钙调节激素功能紊乱密切相关。
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| 关 键 词： | 糖尿病 大鼠 甲状旁腺激素类 骨钙素 降钙素 |
| 文章编号： | 1007-1237(2002)03-0134-02 |
The Changes of Reculating Hormones for Calcium of Experimental Diabetic Rats |
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| Chen Wei,Yang Lan,Chen Wei,et al.. The Changes of Reculating Hormones for Calcium of Experimental Diabetic Rats[J]. Journal of Hainan Medical College, 2002, 8(3): 134-135,138 |
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| Authors: | Chen Wei Yang Lan Chen Wei et al. |
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| Abstract: | Objective:To explore the changes of regulating hormones for calcium in experi-mental diabetic rats.Method:The blood levels of fasting blood-glucose,insulin,bone mineral density(BMD),bone gla protein(BGP),calcitonin(CT),parathyroid hormone(PTH)and vitamin D3of experi-mental diabetic rats and free-feeding rats were measured.Results:The levels of BMD,CT and vita-min D3were significantly decreased(P<0.01),but the level of PTH were significantly increased(P<0.01)for the experimental diabetic rats compared with normal rats.The level of BGP showed rising tendency but had not significantly difference(P>0.05)for the diabetic rats.Conclusion:These results infer that experimental diabetic rats show osteopenia and abnormal calcium regulating hormones and diabetic osteoporosis might be closely related to dysfunction of regulating hormones for calcium. |
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| Keywords: | Diabetes mellitus rats parathyroid hormone osteocalcin calcitonin |
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