Inhibition of apoptosis by bcr-abl fusion gene in K562 cells |
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| Authors: | Wang Chun-hong Sun Bing-zhong Yuan Yue-chuan |
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| Affiliation: | (1) Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, China;(2) Present address: Department of Medicine, 316 Hospital, PLA, 100093 Beijing, China |
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| Abstract: | Objective: To investigate the effect of bcr-abl fusiongene on CML cell apoptosis. Methods: Apoptosis of exvivo cultured K562 cells were observed after exposure tosynthetic 18 mer antisense oligodeoxynucleotide complementary to the bcr-abl junction (b3a2). Results: Apoptosisof K562 cells was significantly increased associated withindibition of bcr-abl expression. Conclusion: bcr-ablfusion gene formation due to chromosome translocationmay be the major mechanism of CML via inhibition ofapoptosis. |
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| Keywords: | Chronic myeloid leukemia bcr-abl fusion gene Apoptosis Antisense oligodeoxynucleotides |
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