不稳定型心绞痛伴糖尿病患者的炎性标志物和纤溶因子的水平及其相关性

目的 探讨高敏C反应蛋白（hs-CRP）、纤溶酶原激活物抑制物-1（PAI-1）在不稳定型心绞痛（UAP）伴糖尿病(DM)患者中水平及其间的相关性。方法 将149例冠心病分为3组:（UAP+DM）组40例，UAP组56例，稳定型心绞痛（SAP）组53例。分别检测入选者血清hs-CRP及血浆PAI-1的水平，分析它们在各组中的水平及它们之间的相关性。结果 UAP+DM组hs-CRP水平高于UAP组［（5.2±2.7）mg/L vs (3.8±1.9)mg/L］和SAP组［（5.2±2.7）mg/L vs (2.0±0.9)mg/L］，UAP组高于SAP组［（3.8±1.9）mg/L vs (2.0±0.9)mg/L］，差异均有统计学意义；血浆PAI-1水平UAP组高于SAP组［（1.8±0.2）A vs (0.7±0.4)A］，差异有统计学意义，而(UAP+DM)组虽高于UAP组［（1.9±0.1）A vs (1.8±0.2)A］，但差异无统计学意义。将149例研究对象以hs-CRP>3 mg/L 为界分为两组，hs-CRP>3 mg/L组PAI-1［（1.7±0.9）A vs (1.2±0.6)A)］、空腹血糖（FPG）［（5.9±1.3）mmol/L vs (5.1±0.7)mmol/L］及UAP发生率（40.94% vs 23.48%）均高于hs-CRP≤3 mg/L组，差异均有统计学意义。相关分析显示，hs-CRP与PAI-1呈正相关，相关系数rs为0.62（P<0.01）；hs-CRP与FPG呈正相关，rs为0.34（P<0.01）；PAI-1与FPG呈正相关，rs为0.38（P<0.01）。结论 （UAP+DM）患者体内的炎症因子hs-CRP、PAI-1水平较单纯UAP及SAP均高。

Correlation between high senstive C-reaction protein and plasminogen activator inhibitor type 1 in patients with unstable anginapectoris and 2 type diabetes mellitus

AIM To explore the role and the correlation between high sensitive C-reaction protein and plasminogen activator inhibitor type 1 in patients of unstable angina pectoris accompanied with 2 type diabetes mellitus. METHOIDS Serum high sensitive C-reactive protein and plasma plasminogen activator inhibitor type 1 levels were measured in 149 subjects, including 40 patients with unstable angina pectoris and 2 type diabetes mellitus (UAP+DM), 56 patients with unstable angina pectors (UAP), and 53 patients with stable angina (SAP). Changes and correlation of the two inflammatory markers in different groups were studied. RESULTS Concentrations of hs-CRP in UAP+DM group were higher than those in UAP group ［(5.2±2.7)mg/L vs (3.8±1.9)mg/L］ and SAP group ［(5.2±2.7)mg/L vs (2.0±0.9)mg/L］, with significant difference. Levels of PAI-1 were also significantly different between the three groups, while the levels of the PAI-1 showed no difference between the UAP+DM group and the UAP group. The levels of the PAI-1 in the subjects with hs-CRP>3 mg/L were (1.7±0.9)A, the levels of the fasting plasma glucose (FPG) were (5.9±1.3)mmol/L and the prevalence rate of the unstable angina pectoris was 40.94%, significantly higher than the subjects with the levels of PAI-1 with hs-CRP≤3 mg/L (1.2±0.6)A, FPG (5.1±0.7)mmol/L and the prevalence rate of the unstable angina pectoris 23.48%. Positive correlation was found between the levels of hs-CRP and PAI-1(r=0.62, P<0.01), between the levels of hs-CRP and FPG (rs=0.34, P<0.01) and between the levels of PAI-1 and FPG (rs=0.38, P<0.01). CONCLUSION Inflammatory factors hs-CRP and PAI-1 in patients with unstable angina pectoris accompanied with Ⅱ type diabetes mellitus are higher than those with only coronary problems or only Ⅱ diabetes mellitus.