Barbiturates in severe head injuries? |
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| Authors: | Dag Moskopp Fernand Ries Hansdetlef Wassmann Joachim Nadstawek |
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| Affiliation: | (1) Department of Neurosurgery, University Hospital Münster, Fed. Rep. of Germany;(2) Department of Neurology, University Hospital Bonn, Fed. Rep. of Germany;(3) Department of Anaesthesiology, University Hospital Bonn, Fed. Rep. of Germany |
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| Abstract: | Possible mechanisms for the therapeutic effects of barbituric acid derivatives in severe head injuries have been discussed for half a century. In the following, a survey of the literature, and a discussion of three controlled clinical studies available until now is presented. A proven effect in terms of a beneficial long-term outcome for all injured patients has not been established.On the other hand there might be a subgroup of patients with an intact CO2 reactivity of the brain vessels who may profit from barbiturates administered after head trauma.Dedicated to Marianne and Gerhard Winkler |
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| Keywords: | Barbiturates brain protection controlled prospective clinical studies head and brain injury hypothetic effective mechanism |
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