脑型利钠肽与非ST段抬高型急性冠脉综合征相关性研究

目的 探讨血浆脑型利钠肽(BNP)与非ST段抬高型急性冠脉综合征的相关性.方法 选择非ST段抬高型急性冠脉综合征患者52例,测定入院即刻、6h、24h及40h的血浆BNP水平,将患者分为BNP增高组与BNP非增高组,给予心脏超声学的检查,观察2组患者6个月内的病死率、心力衰竭、休克发生率及30d后的心肌梗死发生率.结果 BNP增高组患者的恶性事件发生率明显高于非增高组(P＜0.01);心脏超声学检查发现,心脏腔室大小的改变以及左心室功能组间差异无统计学意义(P＞0.05).结论 在急性冠脉综合征患者发病40 h之内测定血浆BNP水平,可以评价患者左心室的功能,预测患者发生致死性及非致死性恶性事件的发生率,临床上有较高的实用价值.

Relationship between non-ST elvation acute coronary ischemic sydrome and BNP

Objective To investigate the relationship between non-ST elevation acute coronary ischemic syndrome and brain natriuretic peptide(BNP).Methods 52 patients with non-ST elevation acutecoronary ischemic syndrome were randomly divided into two groups according to the levels of BNP,BNP enhancement group and non-BNP enhancement group.BNP was examined at 0h,6h,24h and 40h after hospilization.The patients was examined by cardiac ultrasonic inspection.The case fatality within 6 months,the incidence of heart failure and shock,and the incidence of myocardial infarction after 30 days were observed for both groups.Results The incidence of malignant occurrence in BNP enhancement group was significantly higher than that in non-BNP enhancement group(P<0.01).The cardiac ultrasonic inspection showed that there was no significant difference in the change of heart chamber size and left ventricular function between the two groups(P>0.05).Conclusion The measurement of plasma BNP levels in patients with acute coronary ischemic sydrome within 40 h could evaluate patient's left ventricular function and predict the incidence of fatal and non-fatal malignant occurrence,which has an important application value in clinic.